TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3.

Slides:

Advertisements

Similar presentations

P-ERK β-tubulin VSShh + cyclopamine Supplementary Figure ESM 1a ERK MAP Kinase activity is not affected by Shh pathway activity. Western blot analysis.

Advertisements

Darren M Brown, Erkki Ruoslahti Cancer Cell

Histogenic analysis confirms prostate cancer metastasis to lung.

Activation of the Erythropoietin Receptor Is Not Required for Internalization of Bound Erythropoietin by Diana L. Beckman, Lilie L. Lin, Mary E. Quinones,

Detection of CD38+IgG1+ memory B cells adjacent to contracted GCs

Holocrine Secretion of Sebum Is a Unique DNase2-Dependent Mode of Programmed Cell Death Heinz Fischer, Judith Fumicz, Heidemarie Rossiter, Markus Napirei,

Volume 131, Issue 4, Pages (October 2006)

Fluorescence-stained images and respective bright-field images of mouse spleen tissue sections area investigated using Raman spectroscopy. Fluorescence-stained.

Transcription Factor MafB Coordinates Epidermal Keratinocyte Differentiation Masashi Miyai, Michito Hamada, Takashi Moriguchi, Junichiro Hiruma, Akiyo.

Pnut is phosphorylated during early Drosophila embryogenesis.

Deficiency of Cdkn2a leads to aberrant activation of RhoA in vivo.

Volume 7, Issue 2, Pages (February 2010)

Volume 14, Issue 1, Pages (January 2004)

Innervation of Wt1+ neurons and number of commissural neurons in neonatal mice. Innervation of Wt1+ neurons and number of commissural neurons in neonatal.

Selection and Identification of Skeletal-Muscle-Targeted RNA Aptamers

Volume 10, Issue 2, Pages (February 2018)

X-Chromosome Inactivation Patterns Are Unbalanced and Affect the Phenotypic Outcome in a Mouse Model of Rett Syndrome Juan I. Young, Huda Y. Zoghbi

Targeted disruption of the mouse Pex14 gene.

Darren M Brown, Erkki Ruoslahti Cancer Cell

Peroxisomal biogenesis deficiency in skin fibroblasts from a patient with PEX14 mutation. Peroxisomal biogenesis deficiency in skin fibroblasts from a.

Detection and tracking of individual SNAP-tagged proteins on the surface of living cells. Detection and tracking of individual SNAP-tagged proteins on.

Volume 24, Issue 1, Pages (January 2013)

STARD3 favors cholesterol accumulation in endosomes

The absence of the centrosome changes global microtubule dynamics in a migrating cell. The absence of the centrosome changes global microtubule dynamics.

Axonal swelling and impairment of dendritic development in Purkinje cells from Pex14ΔC/ΔC BL/ICR mouse upon treatment with BDNF. Axonal swelling and impairment.

Volume 9, Issue 5, Pages (November 2017)

BDNF expression in the cerebellum and brain stem region.

Melissa L. Ehlers, Barbara Celona, Brian L. Black Cell Reports

Volume 22, Issue 5, Pages e5 (November 2017)

Impaired TrkB signaling in the cerebellum of Pex14ΔC/ΔC BL/ICR mice.

Volume 103, Issue 6, Pages (December 2000)

Control of Centriole Length by CPAP and CP110

Volume 46, Issue 1, Pages (January 2017)

Distinct collagen structures in the upper and lower neonatal dermis (related to Fig 1)‏ Distinct collagen structures in the upper and lower neonatal dermis.

Volume 13, Issue 10, Pages (May 2003)

Volume 22, Issue 5, Pages e5 (November 2017)

Volume 23, Issue 10, Pages (May 2013)

Volume 9, Issue 8, Pages (April 1999)

Kari Barlan, Wen Lu, Vladimir I. Gelfand Current Biology

Volume 15, Issue 3, Pages (September 2008)

STIL Microcephaly Mutations Interfere with APC/C-Mediated Degradation and Cause Centriole Amplification Christian Arquint, Erich A. Nigg Current Biology

Modification of the βIII-tubulin C-terminal tail does not affect the incorporation of the protein into the microtubule network, the microtubule architecture,

Volume 129, Issue 2, Pages (April 2007)

Defect of cerebellar development and malformation of Purkinje cells in Pex14ΔC/ΔC BL/ICR mice. Defect of cerebellar development and malformation of Purkinje.

Volume 8, Issue 3, Pages (August 2014)

Commissural Wt1+ neurons.

Nuclear DNA signal is altered in Chd5-deficient NSCs.

Differential secretion profiles of C. elegans TTR models.

V-SVZ cultures express transcription factors expected for region of origin. V-SVZ cultures express transcription factors expected for region of origin.

Distribution of splenic T cells, B cells, and NK cells in NSG hL-7xhIL-15 humanized mice. Distribution of splenic T cells, B cells, and NK cells in NSG.

Up-regulation of BDNF induces the neurite outgrowth of SH-SY5Y cells.

Occurrence of prominin-1-containing particles in the ventricular fluid of the embryonic mouse brain. Occurrence of prominin-1-containing particles in the.

TSA causes premature chromatid sister separation.

Temporal dynamics of the primitive streak and mesoderm progenitors in β-catenin-activated hES cells. Temporal dynamics of the primitive streak and mesoderm.

Fig. 1. γ-Tubulin localizes in close proximity to centriole walls in interphase but within an extended PCM meshwork in mitosis.U2OS cells were fixed and.

Fcp1 CTD phosphatase affects a broad range of transcripts in the +N and -N media. Fcp1 CTD phosphatase affects a broad range of transcripts in the +N and.

Robo3 in the GnRH neuronal system.

Sox2 regulates dental epithelial stem cell proliferation and differentiation. Sox2 regulates dental epithelial stem cell proliferation and differentiation.

Dissociation of HP1α from H3K9me3 is critical to potentiation of steady-state ATM activity. Dissociation of HP1α from H3K9me3 is critical to potentiation.

Exo70 is recruited to the plasma membrane at sites of mechanical wounding. Exo70 is recruited to the plasma membrane at sites of mechanical wounding. NRK.

DHA induces peroxisome elongation and division in a Pex11pβ-dependent manner. DHA induces peroxisome elongation and division in a Pex11pβ-dependent manner.

Histological analyses for limb-specific Uhrf1 KO mice.

Association of peroxisomes with microtubules is required for proper distribution but not division. Association of peroxisomes with microtubules is required.

Abnormal adherens junctions between hub cells and GSCs in Lar mutants.

Lysine residues in the cytoplasmic region of TfR are involved in the MARCH8-induced downregulation of TfR. Lysine residues in the cytoplasmic region of.

Domain 3, comprising the basolateral calyx and the stretch of axon leading to the heminode, selectively expressed NaV channels, KCNQ3, and certain scaffolding.

Identification of a novel subset of mDA neurons in the VTA that expresses Neurod6, OTX2, CALBINDIN1, ALDH1A1, and Grp. Identification of a novel subset.

Representative macrophage staining images only from the knee joints of CAIA mice injected s.c. with GalNAc–MASP-3–siRNA duplex 2 or GalNAc–luciferase–siRNA.

Gene expression in the PFC of mice with an inducible neuron-specific bdnf knock-out in embryogenesis. Gene expression in the PFC of mice with an inducible.

PC loss in Nhe6-null mouse cerebellum, female and male.

Presentation transcript:

TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3. TrkB-T1 is upregulated in cerebellum of Pex14ΔC/ΔC BL/ICR mouse at P3. (A) Sagittal sections of the cerebellum from wild-type (+/+) and Pex14ΔC/ΔC (ΔC/ΔC) BL/ICR mice were labeled with anti-TrkB (green) and calbindin-D28k (red) antibodies. Scale bar, 20 μm. Higher magnification images of the boxed regions are shown and cell boundaries were indicated as a dashed line (inset). Scale bar, 5 μm. (B) TrkB-positive dots (arrowheads) were quantified (n = 13). (C) Sagittal sections of the cerebellum at P3 were stained with antibodies against vGlut2 (red) and calbindin-D28k (white). The number of dots stained with anti-vGlut2 antibody was quantified (lower panel, n = 4). Scale bar, 10 μm. (D) Sagittal sections of the cerebellum at P3 were stained with antibodies against TrkB (green), vGlut2 (red), and calbindin-D28k (blue). Scale bar, 10 μm. Higher magnification images of the boxed regions are shown (inset). Scale bar, 5 μm. Arrowheads indicate TrkB-positive punctate structures that partly coincided with or are located adjacent to vGlut2-positive punctate structures. (E) Cerebellum lysates were analyzed by SDS-PAGE and immunoblotting with antibodies against TrkB, Pex14pC, and α-tubulin (left panel). TrkB-TK+, full-length TrkB; TrkB-T1, a truncated isoform of TrkB. Amounts of TrkB-TK+ and TrkB-T1 are presented relative to those of TrkB-TK+ in the control mice (middle panel, n = 6). A schematic view of TrkB variants is shown on the right (right panel). TK, tyrosine kinase domain. (F, G) mRNA levels of TrkB-TK+ (F) and TrkB-T1 (G) were quantified by real-time PCR (n = 6). ns, not significant, **P < 0.01, ***P < 0.001, by t test (B, C, E–G). Source data are available for this figure. Yuichi Abe et al. LSA 2018;1:e201800062 © 2018 Abe et al.