Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying.

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Presentation transcript:

Relief in mild-to-moderate pain is not a confounder in joint space narrowing assessment of full extension knee radiographs in recent osteoarthritis structure-modifying drug trials K. Pavelka, M.D, Ph.D., O. Bruyere, Ph.D., L.C. Rovati, M.D., M. Olejárova, M.D., Ph.D., G. Giacovelli, Ph.D., J.-Y. Reginster, M.D., Ph.D. Osteoarthritis and Cartilage Volume 11, Issue 10, Pages 730-737 (October 2003) DOI: 10.1016/S1063-4584(03)00166-3

Fig. 1 WOMAC pain mean (SE) decrease in global knee pain improvers. Panel A reports the data pooled from both studies, while panels B and C show the data from the single studies of Reginster et al. and Pavelka et al., respectively. N represents the number of patients who qualified for the analysis in the placebo and glucosamine sulfate groups. Osteoarthritis and Cartilage 2003 11, 730-737DOI: (10.1016/S1063-4584(03)00166-3)

Fig. 2 Mean (SE) change in joint space width after 3 years in the global knee pain-improver subsets described in Fig. 1. Panel A reports the data pooled from both studies, while panels B and C show the data from the single studies of Reginster et al. and Pavelka et al., respectively. N represents the number of patients who qualified for the analysis in the placebo and glucosamine sulfate groups. The P values presented here were obtained by analysis of variance. Analysis of covariance adjusting for baseline joint space width produced P values of 0.002, 0.048 and 0.046 for panels A, B and C, respectively. Osteoarthritis and Cartilage 2003 11, 730-737DOI: (10.1016/S1063-4584(03)00166-3)

Fig. 3 Mean (SE) change in joint space width after 3 years in the subset of patients with standing knee pain (item #5 in WOMAC pain scale) at least severe at baseline and improving by any degree after 3 years. Panel A reports the data pooled from both studies, while panels B and C show the data from the single studies of Reginster et al. and Pavelka et al., respectively. N represents the number of patients who qualified for the analysis in the placebo and glucosamine sulfate groups, respectively. The P values presented here were obtained by analysis of variance. Analysis of covariance adjusting for baseline joint space width produced P values of 0.017, 0.041 and 0.14 for panels A, B and C, respectively. Osteoarthritis and Cartilage 2003 11, 730-737DOI: (10.1016/S1063-4584(03)00166-3)