Volume 67, Issue 2, Pages (February 2005)

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Volume 67, Issue 2, Pages 732-737 (February 2005) Acute effect of CyA A (Neoral®) on large artery hemodynamics in renal transplant patients  Adrian Covic, Nicoleta Mardare, Paul Gusbeth-Tatomir, Irina Buhaescu, David J.A. Goldsmith  Kidney International  Volume 67, Issue 2, Pages 732-737 (February 2005) DOI: 10.1111/j.1523-1755.2005.67134.x Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 1 Augmentation index as a marker of arterial stiffness. Typical pulse waveforms from normal (top) and stiffened (bottom) conduit arteries derived from percutaneous tonometry tracings. Abbreviations are: S, systole; D, diastole; BP, blood pressure in mm Hg; T0, time of start; TF, time of finish of the cardiac cycle; T1, time to outgoing pressure peak; and T2, time to peak of reflected wave; augmentation index, the augmentation divided by the pulse pressure × 100. The timing of the reflected wave was calculated as T2-T1. Kidney International 2005 67, 732-737DOI: (10.1111/j.1523-1755.2005.67134.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 2 Change in augmentation index (AIx) from moment of cyclosporine A (CyA) administration (C0) to 2 hours after administration (C2). The change corresponds to trough and + 2 hours CyA levels, respectively, for 18 patients. For each patient the two-paired AIx values are presented. Baseline AIx (at C0) is depicted in black while AIx at C2 is depicted in gray. Three patients (1, 3, and 4) were studied twice, the second set of recordings was at > 1 week after the first. Kidney International 2005 67, 732-737DOI: (10.1111/j.1523-1755.2005.67134.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 3 Serial changes in augmentation index (AIx) during a 24-hour period, in relation with cyclosporine A (CyA) administration. Abbreviations are: C0, moment of administration; C2, 2 hours after administration; C6, 6 hours after administration; C12, 12 hours after administration. Kidney International 2005 67, 732-737DOI: (10.1111/j.1523-1755.2005.67134.x) Copyright © 2005 International Society of Nephrology Terms and Conditions

Figure 4 Changes in the timing of the reflected wave at baseline and 2 hours after Neoral® administration. Abbreviations are: T1, time to outgoing pressure peak; T2, time to peak of reflected wave (see also Figure 1). The timing of the reflected wave was calculated as T2- T1. Kidney International 2005 67, 732-737DOI: (10.1111/j.1523-1755.2005.67134.x) Copyright © 2005 International Society of Nephrology Terms and Conditions