Volume 54, Issue 3, Pages (September 1998)

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Volume 54, Issue 3, Pages 857-863 (September 1998) Protection from renal ischemia-reperfusion injury by the 2-methylaminochroman U83836E Elena De Vecchi, Lorenzo Lubatti, Claudio Beretta, Stefano Ferrero, Paola Rinaldi, Marzia Galli Kienle, Rinaldo Trazzi, Rita Paroni Kidney International Volume 54, Issue 3, Pages 857-863 (September 1998) DOI: 10.1046/j.1523-1755.1998.00072.x Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 1 Effects of U83836E after 90minutes renal ischemia plus 2 or 24hours reperfusion. (A) Glutathione redox ratio (free oxidized to total free, ratio %). (B) ATP. Kidneys were treated as described in the Methods section. Values are means ± se. Symbols are: (□) sham-operated animals; (▪) control groups; (▨) treated groups.*P < 0.05 versus control group.§P < 0.05 vs. sham-operated value. Kidney International 1998 54, 857-863DOI: (10.1046/j.1523-1755.1998.00072.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 2 Effects of U83836E after 90minutes renal ischemia plus 2 or 24hours reperfusion. (A) Diene conjugates. (B) Fluorescent products. Kidneys were treated as described under Methods. Values are means ± se. Abbreviations are: U.A., units of absorbance; U.F., units of fluorescence. Symbols are: (□) sham-operated animals; (▪) controls groups; (▨) treated groups. *P < 0.05 vs. control group.§P < 0.05 vs. sham-operated value. Kidney International 1998 54, 857-863DOI: (10.1046/j.1523-1755.1998.00072.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Figure 3 Histological appearance of a cortical field of a rat kidney sacrificed 24hours after 90minutes ischemia. (A) Control kidney. (B) U83836E treated kidney. In the control group, kidney tubular cell necrosis (presence of necrotic cells or denuded areas of tubular basement membrane; arrows) is less discrete and less focally distributed than in the treated animals (hematoxylin and eosin, ×25). Kidney International 1998 54, 857-863DOI: (10.1046/j.1523-1755.1998.00072.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 857-863DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 857-863DOI: (10.1046/j.1523-1755.1998.00072.x) Copyright © 1998 International Society of Nephrology Terms and Conditions

Kidney International 1998 54, 857-863DOI: (10. 1046/j. 1523-1755. 1998 Kidney International 1998 54, 857-863DOI: (10.1046/j.1523-1755.1998.00072.x) Copyright © 1998 International Society of Nephrology Terms and Conditions