Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa,

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Presentation transcript:

Myocyte and endothelial effects of preconditioning the jeopardized heart by inhibiting Na+/H+ exchange Manuel Castellá, MDa, Gerald D. Buckberg, MDa, Zhongtuo Tan, PhDa, Louis J. Ignarro, PhDb The Journal of Thoracic and Cardiovascular Surgery Volume 124, Issue 6, Pages 1113-1121 (December 2002) DOI: 10.1067/mtc.2002.125485 Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 1 Postischemic LV performance assessed by means of Starling curves. SWI, Stroke work index; LAP, left atrial pressure. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 2 Recovery of PRSW expressed as a percentage of preischemic control values. Data are expressed as means ± SD. *P <.05 versus the control group and group 2; **P <.05 versus the control group and group 1. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 3 Levels of CK-MB in units per liter from coronary sinus plasma at baseline and after 30 minutes of reperfusion. Data are expressed as means ± SD. *P <.05 versus group 2 and the control group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 4 Levels of CDS in coronary plasma expressed as absorbance units (A) per 0.5 mL at baseline and after 30 minutes of reperfusion. Data are expressed as means ± SD. *P <.05 versus group 2 and the control group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 5 LV anterior free wall myocardial myeloperoxidase activity taken at the end of the reperfusion period. Data are expressed as means ± SD. *P <.05 versus group 2 and the control group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 6 LV anterior free wall myocardial water content expressed as a percentage of weight taken at the end of the reperfusion period. Data are expressed as means ± SD. *P <.05 versus group 2 and the control group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 7 Levels of ET-1 from coronary sinus plasma at baseline and after 30 minutes of reperfusion. Data are expressed as means ± SD. *P <.05 versus group 2 and the control group. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 8 Change in NO production as a percentage from baseline levels. Data are expressed as means ± SD. *P <.05 versus group 1. The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions

Fig. 9 Pressure-volume loops (above) and stroke work end-diastolic area (PRSWI) (below) in hearts under baseline conditions (A), after ischemia (B), and after ischemia and pretreatment (C). The Journal of Thoracic and Cardiovascular Surgery 2002 124, 1113-1121DOI: (10.1067/mtc.2002.125485) Copyright © 2002 American Association for Thoracic Surgery Terms and Conditions