Volume 10, Issue 4, Pages 327-340 (April 2009) Sensitivity and specificity of multimodal and ultrasound screening for ovarian cancer, and stage distribution of detected cancers: results of the prevalence screen of the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)  Dr Usha Menon, MD, Aleksandra Gentry-Maharaj, PhD, Rachel Hallett, PhD, Andy Ryan, PhD, Matthew Burnell, PhD, Aarti Sharma, MRCOG, Sara Lewis, MSc, Susan Davies, RGN, Susan Philpott, MSc, Alberto Lopes, FRCOG, Keith Godfrey, FRCOG, David Oram, FRCOG, Jonathan Herod, MRCOG, Karin Williamson, FRCOG, Mourad W Seif, FRCOG, Ian Scott, FRCOG, Tim Mould, FRCOG, Robert Woolas, MD, John Murdoch, FRCOG, Stephen Dobbs, MRCOG, Nazar N Amso, PhD, Simon Leeson, FRCOG, Derek Cruickshank, FRCOG, Prof Alistair Mcguire, PhD, Prof Stuart Campbell, DSc Lond, Prof Lesley Fallowfield, DPhil, Naveena Singh, FRCPath, Anne Dawnay, PhD, Steven J Skates, PhD, Prof Mahesh Parmar, PhD, Prof Ian Jacobs, FRCOG  The Lancet Oncology  Volume 10, Issue 4, Pages 327-340 (April 2009) DOI: 10.1016/S1470-2045(09)70026-9 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 Randomisation and initial (prevalence) screen The Lancet Oncology 2009 10, 327-340DOI: (10.1016/S1470-2045(09)70026-9) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 2 Multimodal screening (MMS) algorithm and outcome of initial screen Boxes represent tests (green) or results. Numbers inside boxes indicate the number of volunteers undergoing a specific test or having a certain result. Where a test or result can occur via multiple routes the numbers of volunteers per route are indicated on the arrows. Numbers in square brackets indicate volunteers who deviated from the protocol and the reason. AS=annual screening. CA=diagnosed with other cancer. D=died. S=surgery. W=withdrew. The Lancet Oncology 2009 10, 327-340DOI: (10.1016/S1470-2045(09)70026-9) Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 3 Ultrasound screening (USS) algorithm and outcome of initial screen Boxes represent tests (green) or results. Numbers inside boxes indicate the number of volunteers undergoing a specific test or having a certain result. Where a test or result can occur via multiple routes the numbers of volunteers per route are indicated on the arrows. Numbers in square brackets indicate volunteers who deviated from the protocol and the reason. AS=annual screening. CA=diagnosed with other cancer. D=died. S=surgery. W=withdrew. The Lancet Oncology 2009 10, 327-340DOI: (10.1016/S1470-2045(09)70026-9) Copyright © 2009 Elsevier Ltd Terms and Conditions