Volume 140, Issue 5, Pages e1 (May 2011)

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Volume 140, Issue 5, Pages 1434-1443.e1 (May 2011) Impaired Uptake of Serotonin by Platelets From Patients With Irritable Bowel Syndrome Correlates With Duodenal Immune Activation Stephen Foley, Klara Garsed, Gulzar Singh, Nathalie P. Duroudier, Caroline Swan, Ian P. Hall, Abed Zaitoun, Andrew Bennett, Charles Marsden, Geoffrey Holmes, Andrew Walls, Robin C. Spiller Gastroenterology Volume 140, Issue 5, Pages 1434-1443.e1 (May 2011) DOI: 10.1053/j.gastro.2011.01.052 Copyright © 2011 AGA Institute Terms and Conditions

Figure 1 IEL, mast cell, and EC cell counts in controls and patients with IBS-D. (A) IELs were significantly increased in patients with IBS-D. **P < .01, and in celiac patients ***P < .001. (B) EC cell numbers were not significantly different in patients with IBS-D, but were in celiac patients, P < .001. (C) Mast cells were significantly increased in both patients with IBS-D and patients with celiac disease compared with controls. ***P < .001. Gastroenterology 2011 140, 1434-1443.e1DOI: (10.1053/j.gastro.2011.01.052) Copyright © 2011 AGA Institute Terms and Conditions

Figure 2 Mucosal SERT expression in patients with celiac disease, patients with IBS-D, and controls. SERT/CK20 mRNA showed significant group effect Kruskal–Wallis, P < .0001. SERT/CK20 mRNA was significantly reduced in patients with celiac disease (P < .0001) and to a lesser extent in patients with IBS-D (P < .04). Gastroenterology 2011 140, 1434-1443.e1DOI: (10.1053/j.gastro.2011.01.052) Copyright © 2011 AGA Institute Terms and Conditions

Figure 3 SERT/CK20 mRNA correlation with IEL counts. There was a significant inverse correlation between log10 SERT mRNA normalized for the epithelial cell marker CK20 and log10 IEL counts (Spearman r = 0.72, n = 57, P < .0001). Gastroenterology 2011 140, 1434-1443.e1DOI: (10.1053/j.gastro.2011.01.052) Copyright © 2011 AGA Institute Terms and Conditions

Figure 4 Platelet serotonin uptake and 3H-paroxetine binding in controls, patients with celiac disease, and patients with IBS-D. (A) 5-HT uptake was significantly less in patients with IBS-D (P < .01) compared with healthy controls (see Table 3). (B) Paroxetine binding showed a reversed tendency with significantly increased paroxetine binding in patients with IBS-D (P < .001). Gastroenterology 2011 140, 1434-1443.e1DOI: (10.1053/j.gastro.2011.01.052) Copyright © 2011 AGA Institute Terms and Conditions