The Prognostic Value of the Number of Negative Lymph Nodes in Esophageal Cancer Patients After Transthoracic Resection Po-Kuei Hsu, MD, Chien-Sheng Huang,

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The Prognostic Value of the Number of Negative Lymph Nodes in Esophageal Cancer Patients After Transthoracic Resection Po-Kuei Hsu, MD, Chien-Sheng Huang, MD, Bing-Yen Wang, MD, Yu-Chung Wu, MD, Teh-Ying Chou, MD, PhD, Wen-Hu Hsu, MD The Annals of Thoracic Surgery Volume 96, Issue 3, Pages 995-1001 (September 2013) DOI: 10.1016/j.athoracsur.2013.04.098 Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 (A) There are significant survival differences between group 1 (negative lymph nodes [LN] ≤11 [blue line]), group 2 (negative LN = 12 to 18 [green line]), group 3 (negative LN = 19 to 28 [yellow line]), and group 4 (negative LN ≥29 [red line]). (B) Patients with 19 or more negative LN (groups 3 and 4 [red line]) had significantly better survival rates than patients with less than 18 negative LN (groups 1 and 2 [blue line]). The Annals of Thoracic Surgery 2013 96, 995-1001DOI: (10.1016/j.athoracsur.2013.04.098) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 After stratification by T stage, (A) no survival difference between high negative (red lines) and low negative (blue lines) lymph node (LN) groups was noted in patients with T1/2 stage tumors. (B) However, a significant survival difference was noted in patients with T3/4 stage esophageal cancers. The Annals of Thoracic Surgery 2013 96, 995-1001DOI: (10.1016/j.athoracsur.2013.04.098) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 After stratification by N stage, (A) no survival difference between high negative (red lines) and low negative (blue lines) lymph node (LN) groups was noted in patients with N0 stage tumors. (B) However, a significant survival difference was noted in patients with node-positive esophageal cancers. The Annals of Thoracic Surgery 2013 96, 995-1001DOI: (10.1016/j.athoracsur.2013.04.098) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Among patients with adequate lymph node (LN) staging (TLN ≥15), patients with a high number of negative LN (red line) had significantly better survival than patients with a low number of negative LN (blue line). The Annals of Thoracic Surgery 2013 96, 995-1001DOI: (10.1016/j.athoracsur.2013.04.098) Copyright © 2013 The Society of Thoracic Surgeons Terms and Conditions