Cardiac myocyte functional and biochemical changes after hypothermic preservation in vitro Hiroyuki Orita, MD, Manabu Fukasawa, MD, Shigeki Hirooka,

Slides:

Advertisements

Similar presentations

Objective assessment of gastroesophageal reflux after short esophagomyotomy for achalasia with the use of manometry and pH monitoring John M. Streitz,

Advertisements

The additional hospital costs generated in the management of complications of pacemaker and defibrillator implantations T.Bruce Ferguson, MD, Candice Lilley.

Lost in translation The Journal of Thoracic and Cardiovascular Surgery

Manuel J. Antunes, MD, PhD, DSc

Effects of myocardial ischemia on the release of cardiac troponin I in isolated rat hearts Sidney Chocron, MDa, Kifah Alwan, MDa, Gerard Toubin, MDb,

Inhaled nitric oxide reduces human lung allograft dysfunction

The eighth edition TNM stage classification for lung cancer: What does it mean on main street? Frank C. Detterbeck, MD The Journal of Thoracic and Cardiovascular.

Ralph J. Lewis, MD The Journal of Thoracic and Cardiovascular Surgery

Terje K. Steigen, MD, Ellen Aasum, MS, Truls Myrmel, MD, PhDa, Terje S

The days of future past Neel K. Ranganath, MD, Aubrey C. Galloway, MD

Akihiko Ohkado, MD, Hung Cao-Danh, PhD, K. Eric Sommers, MD, Pedro J

Steven R. Gundry, MD, Matthew A. Romano, MD, O

Victor van Berkel, MD, PhD

Effects of newly developed solutions containing trehalose on twenty-hour canine lung preservation Toru Bando, MD, Shinji Kosaka, MD, Chunjiang Liu, MD,

Glucose-insulin-potassium solutions enhance recovery after urgent coronary artery bypass grafting Harold L. Lazar, MDa, George Philippides, MDb, Carmel.

Shigeyuki Sasaki, MD, PhD (by invitation), James D

New treatment approaches create new disease processes: A short guide on how to reduce unexpected events to a minimum Martin Czerny, MD, MBA The Journal.

Neonatal thymectomy: Does it affect immune function?

The lord of the rings Antonio Miceli, MD, PhD

The unintended consequences in clinical research

Effect of esophageal distention on pressure and electromyographic activity of the pharyngoesophageal sphincter, with identification of the esophagopharyngeal.

Editorial: The core of leadership

P. Ponraj, MS, FRCS, Paolo Masiello, MD, Alun Rees, FRCS

Whole blood heparin concentration measurements by automated protamine titration agree with plasma anti-Xa measurements G.J. Despotis, MD, J.H. Joist,

Juan N. Pulido, MD The Journal of Thoracic and Cardiovascular Surgery

Transvenous versus transthoracic cardioverter-defibrillator implantation: A comparative analysis of morbidity, mortality, and survival David M. Shahian,

Support Your Specialty

Quality of mitral valve surgery at the United States Department of Veterans Affairs Juan A. Crestanello, MD The Journal of Thoracic and Cardiovascular.

T. Carrel, MD, M. Pasic, MD, U. Niederhäuser, MD, M. Turina, MD

It's not “just a shunt” but sometimes it should be…

Cerebral hyperthermia during cardiopulmonary bypass in adults

Do we need a bibliometrician to know which way the wind is blowing?

Intermediate-Term Outcome Of Mitral Reconstruction In Cardiomyopathy

Elucidation of a tripartite mechanism underlying the improvement in cardiac tolerance to ischemia by coenzyme Q10 pretreatment Juan A. Crestanello, MD.

Tissue concentrations of endothelins and functional effects of endothelin-receptor activation in human arteries and veins Peter Holm, MD, Anders Franco-Cereceda,

Commentary: Faster recovery after complex neonatal cardiac surgery

Replicating the success of mitral valve repair in the aortic valve

Patient recovery after intermittent disc escape and spontaneous recession of a mechanical heart valve Francis Robicsek, MD, PhD, Joseph W. Cook, MD

Pretreatment with 3,5,3′ triiodo-l-thyronine (t3): Effects on myocyte contractile function after hypothermic cardioplegic arrest and rewarming Jennifer.

Addition Of A Mast Cell Stabilizing Compound To Organ Preservation Solutions Decreases Lung Reperfusion Injury Mark L. Barr, MD, Joseph N. Carey, BS,

Increase in size of the pulmonary autograft after the ross operation in children: Growth or dilation? Laszlo Solymar, MD, PhD, Göran Südow, MD, Daniel.

Ara K. Pridjian, MD, Edward L. Bove, MD, Flavian M. Lupinetti, MD

Commentary: Do the right thing! Ethical versus legal

R. Pfitzmann, MD, M. Hummel, MD, O. Grauhan, MD, P. Waurick, MD, R

Elspeth M. Brown, MRCP, Anthony P. Salmon, FRCP, Robert K. Lamb, FRCS

Passing the torch The Journal of Thoracic and Cardiovascular Surgery

Carcinoma of the esophagus: Prognostic significance of histologic type

Prognosis and “granularity”: Building on staging foundations?

Thomas W. Rice, MD The Journal of Thoracic and Cardiovascular Surgery

The limits of detectable cerebral perfusion by transcranial doppler sonography in neonates undergoing deep hypothermic low-flow cardiopulmonary bypass

T. Brett Reece, MD The Journal of Thoracic and Cardiovascular Surgery

P.K. Spanos, MD, A.D. Bisbos, MD, I.I. Arditis, MD

Heart transplantation in patients with previous cardiac operations:

Postbypass effects of delayed rewarming on cerebral blood flow velocities in infants after total circulatory arrest Rosendo A. Rodriguez, MD, PhDa (by.

Early extubation after cardiac surgery: The evolution continues

The Journal of Thoracic and Cardiovascular Surgery

Discussion The Journal of Thoracic and Cardiovascular Surgery

Tissue valve, nitinol stent, or storage solution

The future of cardiac surgery training: A survival guide

Apparently, size matters…in congenital heart disease and brain injury

Ventricular assistant in restrictive cardiomyopathy: Making the right connection Robert D.B. Jaquiss, MD The Journal of Thoracic and Cardiovascular Surgery

AATS 94th Annual Meeting The Journal of Thoracic and Cardiovascular Surgery Volume 147, Issue 1, Pages (January 2014) DOI: /S (13)

“The more things change…”: The challenges ahead

First in line for robotic surgery: Would you want to know?

Loss of endothelium-dependent vasodilatation and nitric oxide release after myocardial protection with University of Wisconsin solution Jeffrey M. Pearl,

Masao Takahashi, MD, Shinichiro Yamamoto, MD, Shigeki Tabata, MD

The Impact of New Technology on Cardiothoracic Surgical Practice

Journal changes and initiatives

Contribution of hyperoxia to lipid peroxidation in coronary artery operations: Should we keep a low oxygen tension? Leonidas Hadjinikolaou, MD, Andrew.

S. Tabbutt, MD, PhDa b d e, B. W. Duncan, MDc f, D. McLaughlin, RNg, D

Presentation transcript:

Cardiac myocyte functional and biochemical changes after hypothermic preservation in vitro Hiroyuki Orita, MD, Manabu Fukasawa, MD, Shigeki Hirooka, MD, Hideaki Uchino, MD, Kana Fukui, MD, Minoru Kohi, MD, Masahiko Washio, MD The Journal of Thoracic and Cardiovascular Surgery Volume 107, Issue 1, Pages 226-232 (January 1994) DOI: 10.5555/uri:pii:S0022522394704759 Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 1 Cardiac myocyte beating rate associated with various plating densities. Each data point represents geometric mean of five experiments. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 226-232DOI: (10.5555/uri:pii:S0022522394704759) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 2 Recovery ratio of myocyte beating rate measured 24 hours after various hypothermic incubation times (6, 12, 18, and 24 hours) at 4° C with four types of storage solutions: SS, ECS, UWS, and MM. Each value is expressed as percentage of control (i.e., beating rate before hypothermic incubation) and represents mean plus or minus standard deviation of seven experiments. Significant differences of each group are as follows: 6 hours: MM versus UWS, p < 0.05; SS versus ECS, p < 0.005; 12 hours: MM versus UWS and SS, p < 0.001 and 0.005; ECS versus UWS and SS, p < 0.05; 18 hours: MM versus UWS, p < 0.02; 24 hours: MM versus UWS, p < 0.001. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 226-232DOI: (10.5555/uri:pii:S0022522394704759) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 3 CK levels in incubation medium after various hypothermic incubation times at 4° C with four types of storage solutions. Each value represents mean plus or minus standard deviation of seven experiments. Significant differences of each group are as follows: 6 and 12 hours: ECS versus MM, SS, and UWS, p < 0.001; 18 hours: ECS versus SS, p < 0.02, MM and UWS, p < 0.001; 24 hours: MM versus SS and UWS, p < 0.005, ECS versus MM, SS, and UWS, p < 0.001. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 226-232DOI: (10.5555/uri:pii:S0022522394704759) Copyright © 1994 Mosby, Inc. Terms and Conditions

Fig. 4 LDH levels in incubation medium after various hypothermic incubation times at 4° C with four types of storage solutions. Each value represents mean plus or minus standard deviation of seven experiments. Significant differences of each group are as follows: 6 hours: ECS versus MM, SS, and UWS, p < 0.01; 12hours: ECS versus MM, SS, and UWS, p < 0.001; 18 hours: MM versus SS, p < 0.005, UWS versus SS, p < 0.05, ECS versus MM, SS, and UWS, p < 0.05; 24 hours: MM versus UWS and SS, p < 0.05, 0.001, UWS versus SS, p < 0.005, ECS versus SS, p < 0.005, MM, and UWS, 0.001. The Journal of Thoracic and Cardiovascular Surgery 1994 107, 226-232DOI: (10.5555/uri:pii:S0022522394704759) Copyright © 1994 Mosby, Inc. Terms and Conditions