Association Between Caffeine Intake and All-Cause and Cause-Specific Mortality: A Population-Based Prospective Cohort Study Tetsuro Tsujimoto, MD, PhD,

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Association Between Caffeine Intake and All-Cause and Cause-Specific Mortality: A Population-Based Prospective Cohort Study Tetsuro Tsujimoto, MD, PhD, Hiroshi Kajio, MD, PhD, Takehiro Sugiyama, MD, MSHS, PhD Mayo Clinic Proceedings Volume 92, Issue 8, Pages 1190-1202 (August 2017) DOI: 10.1016/j.mayocp.2017.03.010 Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 1 Hazard ratios for all-cause mortality according to daily caffeine intake. The reference line at 1.0 corresponds to the reference group with a caffeine intake of less than 10 mg/d. Mayo Clinic Proceedings 2017 92, 1190-1202DOI: (10.1016/j.mayocp.2017.03.010) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 2 Association between coffee consumption and caffeine intake. Caffeine intake (A) and proportion of caffeine intake of less than 10 mg/d (B) according to coffee consumption. Caffeine intake (C) and proportion of caffeine intake of less than 10 mg/d (D) according to decaffeinated coffee consumption. Mayo Clinic Proceedings 2017 92, 1190-1202DOI: (10.1016/j.mayocp.2017.03.010) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions

Figure 3 Hazard ratios for all-cause mortality according to daily caffeine intake in participants who consumed less than 1 cup of coffee per week. The reference line at 1.0 corresponds to the reference group with a caffeine intake of less than 10 mg/d. Mayo Clinic Proceedings 2017 92, 1190-1202DOI: (10.1016/j.mayocp.2017.03.010) Copyright © 2017 Mayo Foundation for Medical Education and Research Terms and Conditions