Assignment of the Gene for a New Hereditary Nail Disorder, Isolated Congenital Nail Dysplasia, to Chromosome 17p13 Alice Krebsová, Henning Hamm, Susanne.

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Assignment of the Gene for a New Hereditary Nail Disorder, Isolated Congenital Nail Dysplasia, to Chromosome 17p13 Alice Krebsová, Henning Hamm, Susanne Karl, André Reis, Hans Christian Hennies Journal of Investigative Dermatology Volume 115, Issue 4, Pages 664-667 (October 2000) DOI: 10.1046/j.1523-1747.2000.00102.x Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Clinical features of ICND. (a) ICND in a 9 y old girl. All fingernails of the left hand show thinning and longitudinal streaks. Some lunulae are poorly developed. (b) ICND in a 7 y old boy. The nail plates of the thumbs are striated and seem to broaden distally by overgrowing the lateral nail folds. (c) ICND in a 15 y old male. A marked longitudinal ridge arises from a small reddish dome-shaped prominence adjacent to the proximal nail fold and turns in a notch of the free nail margin. Journal of Investigative Dermatology 2000 115, 664-667DOI: (10.1046/j.1523-1747.2000.00102.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Pedigree of the investigated ICND family and construction of haplotypes. (a) Complete pedigree. The filled symbols indicate individuals affected by ICND. The high number of affected females and males in all generations shows an autosomal dominant mode of inheritance with full penetrance. (b) Excerpts from the pedigree with corresponding haplotypes showing the decisive recombination events. The black bar represents the affected haplotype that was found in all affected family members. A change of filled bar to open bar indicates a recombination event. Recombination events determining the ICND interval were identified in individuals 10, 34, and 37. Journal of Investigative Dermatology 2000 115, 664-667DOI: (10.1046/j.1523-1747.2000.00102.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Localization of the ICND gene. The 6 cM interval containing the ICND gene on chromosome 17p13 is flanked by the markers at D17S926 and D17S1528. Journal of Investigative Dermatology 2000 115, 664-667DOI: (10.1046/j.1523-1747.2000.00102.x) Copyright © 2000 The Society for Investigative Dermatology, Inc Terms and Conditions