Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis Daniel.

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Treatment with an oral small molecule inhibitor of P selectin (PSI-697) decreases vein wall injury in a rat stenosis model of venous thrombosis Daniel D. Myers, DVM, MPH, Peter K. Henke, MD, Patricia W. Bedard, BS, Shirley K. Wrobleski, BS, Neelu Kaila, PhD, Gray Shaw, PhD, Thomas R.. Meier, DVM, Angela E. Hawley, MS, Robert G. Schaub, PhD, Thomas W. Wakefield, MD Journal of Vascular Surgery Volume 44, Issue 3, Pages 625-632 (September 2006) DOI: 10.1016/j.jvs.2006.05.021 Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 1 Rat inferior vena cava (IVC) stenosis model of venous thrombosis. Journal of Vascular Surgery 2006 44, 625-632DOI: (10.1016/j.jvs.2006.05.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 2 Study design using the rat stenosis model of deep venous thrombosis. IVC, Inferior vena cava. Journal of Vascular Surgery 2006 44, 625-632DOI: (10.1016/j.jvs.2006.05.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 3 Vein wall tensiometric analysis. LOV, Lovenox (enoxaparin); CTR, control; NORM, normal. Journal of Vascular Surgery 2006 44, 625-632DOI: (10.1016/j.jvs.2006.05.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 4 Vein wall intimal thickness scoring. LOV, Lovenox (enoxaparin); CTR, control. Journal of Vascular Surgery 2006 44, 625-632DOI: (10.1016/j.jvs.2006.05.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 5 A, Vein wall interleukin 13 antigen levels. LOV, Lovenox (enoxaparin); CTR, control; NORM, normal. B, Vein wall monocyte chemotactic protein 1/JE (MCP-1/JE) antigen levels. C, Vein wall platelet-derived growth factor ββ (PDGF-BB) antigen levels. Journal of Vascular Surgery 2006 44, 625-632DOI: (10.1016/j.jvs.2006.05.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions

Fig 6 Vein wall morphometrics. LOV, Lovenox (enoxaparin); CTR, control; TC, total inflammatory cell; MONO, monocytes; LYMPH, lymphocytes; PMN, polymorphonuclear cells; HPF, high-power field. Journal of Vascular Surgery 2006 44, 625-632DOI: (10.1016/j.jvs.2006.05.021) Copyright © 2006 The Society for Vascular Surgery Terms and Conditions