Volume 7, Issue 1, Pages (April 2000)

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Volume 7, Issue 1, Pages 53-61 (April 2000) Induction of c-fos and interleukin-2 genes expression in the central nervous system following stressor stimuli T.B. Kazakova, S.V. Barabanova, N.S. Novikova, M.A. Nosov, V. Rogers, E.A. Korneva Pathophysiology Volume 7, Issue 1, Pages 53-61 (April 2000) DOI: 10.1016/S0928-4680(00)00029-8

Fig. 1 Photomicrographs illustrated the localization of c-fos mRNA in the dorsal horns of the spinal cord. Sections were taken from animals injected with 5% mustard in vegetable oil. (a) c-fos mRNA-intact animal, (b) c-fos mRNA-stimulated animal. Pathophysiology 2000 7, 53-61DOI: (10.1016/S0928-4680(00)00029-8)

Fig. 2 Photomicrographs illustrated the localization of c-fos mRNA and IL-2 m RNA in the lateral hypothalamic area. Sections were taken from animals injected with 5% mustard in vegetable oil 2 h after the injection. Expression of: (a) c-fos mRNA-intact animal; (b) c-fos mRNA stimulated animal; (c) IL-2 mRNA-intact animal; (d) IL-2 mRNA-stimulated animal. Pathophysiology 2000 7, 53-61DOI: (10.1016/S0928-4680(00)00029-8)

Fig. 2 Photomicrographs illustrated the localization of c-fos mRNA and IL-2 m RNA in the lateral hypothalamic area. Sections were taken from animals injected with 5% mustard in vegetable oil 2 h after the injection. Expression of: (a) c-fos mRNA-intact animal; (b) c-fos mRNA stimulated animal; (c) IL-2 mRNA-intact animal; (d) IL-2 mRNA-stimulated animal. Pathophysiology 2000 7, 53-61DOI: (10.1016/S0928-4680(00)00029-8)

Fig. 2 Photomicrographs illustrated the localization of c-fos mRNA and IL-2 m RNA in the lateral hypothalamic area. Sections were taken from animals injected with 5% mustard in vegetable oil 2 h after the injection. Expression of: (a) c-fos mRNA-intact animal; (b) c-fos mRNA stimulated animal; (c) IL-2 mRNA-intact animal; (d) IL-2 mRNA-stimulated animal. Pathophysiology 2000 7, 53-61DOI: (10.1016/S0928-4680(00)00029-8)

Fig. 2 Photomicrographs illustrated the localization of c-fos mRNA and IL-2 m RNA in the lateral hypothalamic area. Sections were taken from animals injected with 5% mustard in vegetable oil 2 h after the injection. Expression of: (a) c-fos mRNA-intact animal; (b) c-fos mRNA stimulated animal; (c) IL-2 mRNA-intact animal; (d) IL-2 mRNA-stimulated animal. Pathophysiology 2000 7, 53-61DOI: (10.1016/S0928-4680(00)00029-8)

Fig. 3 Distribution of c-fos mRNA and IL-2 mRNA in the different brain structures. The Swanson's stereotaxic rat brain atlas was used for the drawings (the layer N 26). Drawings illustrate the distribution of c-fos mRNA and IL-2 mRNA in the brain 2 h after 5% mustard in vegetable oil injection: (A) c-fos mRNA-intact animals; (B) c-fos mRNA-stimulated animals; (C) IL-2 mRNA-intact animals; (D) IL-2 mRNA-stimulated animals. In a frame on the scheme the average amount of labeled cells shows distribution of c-fos mRNA or IL-2 mRNA in different layers of the sensori-motor zone of the brain cortex. Pathophysiology 2000 7, 53-61DOI: (10.1016/S0928-4680(00)00029-8)

Fig. 4 Distribution of the Dig-IL-2 mRNA in different cells in the different parts of the brain after 5% mustard in vegetable oil injection. The arrows indicate: (a) unlabeled cells, (b) label in the nucleus, (c) label in the peripheria of the nucleus. The data demonstrated IL-2 mRNA transport from the nuclei to the cytoplasma. Pathophysiology 2000 7, 53-61DOI: (10.1016/S0928-4680(00)00029-8)