Drug-eluting balloon angioplasty versus uncoated balloon angioplasty in patients with femoropopliteal arterial occlusive disease Hidde Jongsma, MD, Joost.

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Drug-eluting balloon angioplasty versus uncoated balloon angioplasty in patients with femoropopliteal arterial occlusive disease Hidde Jongsma, MD, Joost A. Bekken, MD, Jean-Paul P.M. de Vries, MD, PhD, Hence J. Verhagen, MD, PhD, Bram Fioole, MD, PhD Journal of Vascular Surgery Volume 64, Issue 5, Pages 1503-1514 (November 2016) DOI: 10.1016/j.jvs.2016.05.084 Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 1 Trial selection process according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis Statement (PRISMA) statements.22 Journal of Vascular Surgery 2016 64, 1503-1514DOI: (10.1016/j.jvs.2016.05.084) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 2 Evaluation of risk of bias. Journal of Vascular Surgery 2016 64, 1503-1514DOI: (10.1016/j.jvs.2016.05.084) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 3 Binary restenosis (A) after 6 months and (B) after 1 year. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CI. The solid vertical line indicates no effect. DEB, Drug-eluting balloon; M-H, Mantel-Haenszel; UCB, uncoated balloon. Journal of Vascular Surgery 2016 64, 1503-1514DOI: (10.1016/j.jvs.2016.05.084) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 4 Late lumen loss (LLL) after 6 months. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CI. The solid vertical line indicates no effect. DEB, Drug-eluting balloon; IV, inverse variance; SD, standard deviation; UCB, uncoated balloon. Journal of Vascular Surgery 2016 64, 1503-1514DOI: (10.1016/j.jvs.2016.05.084) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 5 Target lesion revascularization (TLR) (A) after 1 year and (B) after 2 years. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CI. The solid vertical line indicates no effect. DEB, Drug-eluting balloon; M-H, Mantel-Haenszel; UCB, uncoated balloon. Journal of Vascular Surgery 2016 64, 1503-1514DOI: (10.1016/j.jvs.2016.05.084) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 6 Major amputation after 12 months. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CI. The solid vertical line indicates no effect. DEB, Drug-eluting balloon; M-H, Mantel-Haenszel; UCB, uncoated balloon. Journal of Vascular Surgery 2016 64, 1503-1514DOI: (10.1016/j.jvs.2016.05.084) Copyright © 2016 Society for Vascular Surgery Terms and Conditions

Fig 7 Mortality after 12 months. The solid squares indicate the mean difference and are proportional to the weights used in the meta-analysis. The horizontal lines represent the 95% confidence interval (CI). The diamond indicates the weighted mean difference, and the lateral tips of the diamond indicate the associated 95% CI. The solid vertical line indicates no effect. DEB, Drug-eluting balloon; M-H, Mantel-Haenszel; UCB, uncoated balloon. Journal of Vascular Surgery 2016 64, 1503-1514DOI: (10.1016/j.jvs.2016.05.084) Copyright © 2016 Society for Vascular Surgery Terms and Conditions