Gastrointestinal manifestations in mastocytosis: A study of 83 patients Harry Sokol, MD, PhD, Sophie Georgin-Lavialle, MD, PhD, Danielle Canioni, MD,

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Presentation transcript:

Gastrointestinal manifestations in mastocytosis: A study of 83 patients Harry Sokol, MD, PhD, Sophie Georgin-Lavialle, MD, PhD, Danielle Canioni, MD, Stéphane Barete, MD, PhD, Gandhi Damaj, MD, Erinn Soucie, PhD, Julie Bruneau, MD, Marie-Olivia Chandesris, MD, Felipe Suarez, MD, PhD, Jean-Marie Launay, PharmD, PhD, Achille Aouba, MD, Catherine Grandpeix-Guyodo, MD, Fanny Lanternier, MD, Bernard Grosbois, MD, Christian de Gennes, MD, Pascal Cathébras, MD, Olivier Fain, MD, Nadia Hoyeau-Idrissi, MD, Patrice Dubreuil, PhD, Olivier Lortholary, MD, PhD, Laurent Beaugerie, MD, PhD, Brigitte Ranque, MD, PhD, Olivier Hermine, MD, PhD Journal of Allergy and Clinical Immunology Volume 132, Issue 4, Pages 866-873.e3 (October 2013) DOI: 10.1016/j.jaci.2013.05.026 Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Number of liquid stools per week reported for patients with mastocytosis grouped according to WT or mutated (MUT) c-Kit detected in skin lesions. Journal of Allergy and Clinical Immunology 2013 132, 866-873.e3DOI: (10.1016/j.jaci.2013.05.026) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Examples of MC infiltration of the gastrointestinal tract. Biopsy specimens of the stomach, small bowel, and colon from healthy subjects and patients with mastocytosis undergoing immunohistochemistry with anti-CD117 antibody (Gx200) and anti-tryptase antibody (Gx100 for stomach biopsy specimens and Gx200 for small bowel and colon biopsy specimens) are shown. Black arrows show MCs. Journal of Allergy and Clinical Immunology 2013 132, 866-873.e3DOI: (10.1016/j.jaci.2013.05.026) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Gastrointestinal symptoms and history questionnaire. Journal of Allergy and Clinical Immunology 2013 132, 866-873.e3DOI: (10.1016/j.jaci.2013.05.026) Copyright © 2013 American Academy of Allergy, Asthma & Immunology Terms and Conditions