Development of acute tolerance to the EEG effect of propofol in rats†

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Presentation transcript:

Development of acute tolerance to the EEG effect of propofol in rats† H Ihmsen, M Schywalsky, A Tzabazis, H Schwilden British Journal of Anaesthesia Volume 95, Issue 3, Pages 367-371 (September 2005) DOI: 10.1093/bja/aei179 Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 1 Modified EEG median frequency (mMEF) and measured propofol plasma concentrations in a representative case. Time is given in minutes after start of closed-loop control. The set point of 3.0 (0.5) Hz is indicated by the grey bar. British Journal of Anaesthesia 2005 95, 367-371DOI: (10.1093/bja/aei179) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 2 Modified EEG median frequency (mMEF), spectral edge frequency (SEF90) and approximate entropy for all animals (mean and sd). The grey bar at the bottom indicates the time of closed-loop control. British Journal of Anaesthesia 2005 95, 367-371DOI: (10.1093/bja/aei179) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 3 Cumulative doses for each animal during closed-loop infusion of propofol. The bold line represents the mean for all rats. British Journal of Anaesthesia 2005 95, 367-371DOI: (10.1093/bja/aei179) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 4 Measured propofol concentrations for all animals (mean and se). The grey bar at the bottom indicates the time of closed-loop control. *P<0.05 vs concentration at t=0. British Journal of Anaesthesia 2005 95, 367-371DOI: (10.1093/bja/aei179) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions

Fig 5 Mean arterial pressure (MAP) for all animals (mean and sd). The grey bar at the bottom indicates the time of closed-loop control. British Journal of Anaesthesia 2005 95, 367-371DOI: (10.1093/bja/aei179) Copyright © 2005 British Journal of Anaesthesia Terms and Conditions