Calcification or Not. This Is the Question

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Presentation transcript:

Calcification or Not. This Is the Question Calcification or Not. This Is the Question. A 1-Year Study of Bovine Pericardial Vascular Patches (CardioCel) in Minipigs Aida Salameh, MD, PhD, Wiebke Greimann, DVM, David Vondrys, MD, PhD, Martin Kostelka, MD, PhD Seminars in Thoracic and Cardiovascular Surgery Volume 30, Issue 1, Pages 54-59 (March 2018) DOI: 10.1053/j.semtcvs.2017.09.013 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Examples of 2 CardioCel patches implanted in the high-pressure system (aorta ascendens). (A, B) von Kossa staining and (C, D) van Gieson staining of 2 different patches (pigs 1 and 2). Panels A and B show severe calcification (black) within the patch area. Parts of the calcified crumbly material floated off during the staining process, leaving a hole within the calcified area. The arrows indicate where the patch has been implanted. (E, F) Safranin-O-light green staining (for the detection of cartilage). Arrows indicate the chondrified areas (pig 3). (F) is a magnification of (E). (Color version of figure is available online.) Seminars in Thoracic and Cardiovascular Surgery 2018 30, 54-59DOI: (10.1053/j.semtcvs.2017.09.013) Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 2 Examples of 2 CardioCel patches implanted in the low-pressure system (arteria pulmonalis). (A, B) von Kossa staining and (C, D) van Gieson staining of 2 different patches (pig 4 and pig 1). Panels A and B show severe calcification (black) within the patch area. Parts of the calcification floated off the slide during the staining process. The arrows indicate where the patch has been implanted. (E, F) Safranin-O-light green staining for the detection of cartilage. Arrows point to chondrified areas (pig 4). (F) is a magnification of (E). (Color version of figure is available online.) Seminars in Thoracic and Cardiovascular Surgery 2018 30, 54-59DOI: (10.1053/j.semtcvs.2017.09.013) Copyright © 2017 Elsevier Inc. Terms and Conditions

Pulmonary artery: severe calcification of implanted CardioCel patch (black arrow). Seminars in Thoracic and Cardiovascular Surgery 2018 30, 54-59DOI: (10.1053/j.semtcvs.2017.09.013) Copyright © 2017 Elsevier Inc. Terms and Conditions