IL-17 Responses Are the Dominant Inflammatory Signal Linking Inverse, Erythrodermic, and Chronic Plaque Psoriasis  Xianying Xing, Yun Liang, Mrinal K. Sarkar, Liza Wolterink, William R. Swindell, John J. Voorhees, Paul W. Harms, Joanne M. Kahlenberg, Andrew Johnston, Johann E. Gudjonsson  Journal of Investigative Dermatology  Volume 136, Issue 12, Pages 2498-2501 (December 2016) DOI: 10.1016/j.jid.2016.07.008 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Unique and shared canonical pathways between chronic plaque, inverse, and erythrodermic psoriasis. Venn diagram of the overlap between chronic plaque, inverse, and erythrodermic psoriasis and enriched canonical pathways. (a) The overlap group represented most differentially expressed genes in both the inverse and erythrodermic groups (>66%) but only about 12% of the differentially expressed genes in chronic plaque psoriasis. The dominant canonical pathway in the shared group was IL-17 responses. (b) Histologic confirmation of several genes shared between chronic plaque, inverse, and erythrodermic psoriasis (scale bar = 100 μm). ERYTH, erythrodermic psoriasis; Erythrod, erythrodermic psoriasis; INV, inverse psoriasis; KRT, keratin; PP, chronic plaque psoriasis. Journal of Investigative Dermatology 2016 136, 2498-2501DOI: (10.1016/j.jid.2016.07.008) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Overlapping and unique biologic and cytokine responses in chronic plaque, inverse, and erythrodermic psoriasis. (a) On the basis of biologic process analyses by Cytoscape and ClueGO (www.cytoscape.org), the shared genes between chronic plaque, inverse, and erythrodermic psoriasis belonged to five major groups, including keratinocyte differentiation and response to cytokine. (b) From gene-set enrichment analyses, IL-17a signatures were observed to dominate the shared gene set, along with IL-17a + tumor necrosis factor and tumor necrosis factor responses. (c) Quantitative real-time reverse transcriptase–PCR of chronic plaque (n = 12), inverse (n = 40), and erythrodermic psoriasis (n = 30) showed differences in the mRNA expression of key cytokines among the three clinical presentations. Data shown with standard error of the mean, two-tailed t test. ∗P < 0.05, ∗∗P < 0.01, ∗∗∗P < 0.001. Eryth, erythrodermic psoriasis; Inv, inverse psoriasis; NN, normal skin; PP, chronic plaque psoriasis; OSM, oncostatin M; TGF, transforming growth factor; TNF, tumor necrosis factor. Journal of Investigative Dermatology 2016 136, 2498-2501DOI: (10.1016/j.jid.2016.07.008) Copyright © 2016 The Authors Terms and Conditions