R.N. Upton, G.L. Ludbrook, A.M. Martinez, C Grant, R.W. Milne

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Presentation transcript:

Cerebral and lung kinetics of morphine in conscious sheep after short intravenous infusions R.N. Upton, G.L. Ludbrook, A.M. Martinez, C Grant, R.W. Milne British Journal of Anaesthesia Volume 90, Issue 6, Pages 750-758 (June 2003) DOI: 10.1093/bja/aeg131 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 (a) Mean (symbols) and 95% confidence intervals (dotted lines) of the index of cerebral blood flow (CBF) expressed as a percentage of baseline values in six sheep. (b) Equivalent data for the measured mean arterial pressure (MAP) and (c) arterial carbon dioxide tension (PaCO2). The solid lines are the baseline values. Statistically significant changes from baseline were inferred if the 95% confidence intervals for a subsequent measurement did not include the mean baseline value. This did not occur for any of the measurements. British Journal of Anaesthesia 2003 90, 750-758DOI: (10.1093/bja/aeg131) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 (a) Measured pulmonary artery (triangle) and arterial concentrations (circle) of morphine in four sheep. (b) Measured arterial (circle) and sagittal-sinus (inverted triangle) concentrations of morphine in five sheep. Data are shown as the mean at each time point. The variability of the data can be deduced from Figure 3. Solid lines are the best fit of the kinetic model with the highest model selection criteria. These were the ‘flow limited with loss’ model for the lungs (Table 1), and the membrane-limited model with V1 fixed for the brain (Table 2). British Journal of Anaesthesia 2003 90, 750-758DOI: (10.1093/bja/aeg131) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 3 Mean (symbols) and 95% confidence intervals (dotted lines) of the individual concentration differences across the lungs (pulmonary artery–arterial) in four sheep (a) and of the individual concentration differences across the brain (arterial–sagittal sinus) in five sheep (b). British Journal of Anaesthesia 2003 90, 750-758DOI: (10.1093/bja/aeg131) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions