Interdialytic Weight Gain: Trends, Predictors, and Associated Outcomes in the International Dialysis Outcomes and Practice Patterns Study (DOPPS)  Michelle.

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Interdialytic Weight Gain: Trends, Predictors, and Associated Outcomes in the International Dialysis Outcomes and Practice Patterns Study (DOPPS)  Michelle M.Y. Wong, MD, MSc, FRCPC, Keith P. McCullough, MS, Brian A. Bieber, MPH, MS, Juergen Bommer, MD, Manfred Hecking, MD, Nathan W. Levin, MD, William M. McClellan, MD, MPH, Ronald L. Pisoni, PhD, MS, Rajiv Saran, MD, MRCP, MS, Francesca Tentori, MD, MS, Tadashi Tomo, MD, Friedrich K. Port, MD, MS, Bruce M. Robinson, MD, MS  American Journal of Kidney Diseases  Volume 69, Issue 3, Pages 367-379 (March 2017) DOI: 10.1053/j.ajkd.2016.08.030 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Trends in interdialytic weight gain (IDWG) by region across Dialysis Outcomes and Practice Patterns Study (DOPPS) phases among 21,919 patients (phase 2: 2002-2004, phase 3: 2005-2008, phase 4: 2009-2011, phase 5: 2012-2014). (A) Relative IDWG, as percent of posthemodialysis (post-HD) weight; 95% confidence intervals are shown. (B) Absolute IDWG (kg); 95% confidence intervals are shown. (C) Proportion of patients by relative IDWG (percent age of post-HD weight) category. (D) Mean facility-level relative IDWG (percent age of post-HD weight). The box shows the 25th to 75th percentile, and the whiskers, the 5th to 95th percentile. ∗P for trend < 0.05. ∗∗P for trend < 0.001. Abbreviations: ANZ, Australia/New Zealand; US, United States. American Journal of Kidney Diseases 2017 69, 367-379DOI: (10.1053/j.ajkd.2016.08.030) Copyright © 2016 The Authors Terms and Conditions

Figure 2 Trends in systolic blood pressure (SBP) by region across Dialysis Outcomes and Practice Patterns Study (DOPPS) phases (phase 2: 2002-2004, phase 3: 2005-2008, phase 4: 2009-2011, phase 5: 2012-2014) among 21,845 patients; 95% confidence intervals are shown. (A) Prehemodialysis (pre-HD) SBP. (B) Post-HD SBP. (C) ΔSBP (pre-HD SBP – post-HD SBP). ∗P for trend < 0.05. ∗∗P for trend < 0.001. Abbreviations: ANZ, Australia/New Zealand; US, United States. American Journal of Kidney Diseases 2017 69, 367-379DOI: (10.1053/j.ajkd.2016.08.030) Copyright © 2016 The Authors Terms and Conditions

Figure 3 Trends in (A) dialysate sodium (DNa) and (B) serum sodium (SNa) and (C) sodium gradient (GNa = DNa − SNa) values by region across Dialysis Outcomes and Practice Patterns Study (DOPPS) phases (phase 2: 2002-2004, phase 3: 2005-2008, phase 4: 2009-2011, and phase 5: 2012-2014), among 19,192 patients; 95% confidence intervals are shown. ∗P for trend < 0.05. ∗∗P for trend < 0.001. Abbreviations: ANZ, Australia/New Zealand; US, United States. American Journal of Kidney Diseases 2017 69, 367-379DOI: (10.1053/j.ajkd.2016.08.030) Copyright © 2016 The Authors Terms and Conditions

Figure 4 Associations between relative interdialytic weight gain (IDWG) and risk for all-cause mortality in patients with and without residual kidney function (RKF) among 17,864 patients (4,593 with RKF and 13,271 without RKF). Fully adjusted hazard ratios with 95% confidence intervals (CIs) are shown. Abbreviation: HD, hemodialysis. American Journal of Kidney Diseases 2017 69, 367-379DOI: (10.1053/j.ajkd.2016.08.030) Copyright © 2016 The Authors Terms and Conditions

Figure 5 Associations between relative interdialytic weight gain (IDWG) and risk for all-cause and cause-specific hospitalizations (among 21,919 patients in all-cause hospitalization analysis and among 19,000 patients in cause-specific hospitalization analysis). Fully adjusted hazard ratios with 95% confidence intervals (CIs) are shown. Abbreviation: HD, hemodialysis. American Journal of Kidney Diseases 2017 69, 367-379DOI: (10.1053/j.ajkd.2016.08.030) Copyright © 2016 The Authors Terms and Conditions