Effects of tirofiban on haemostatic activation in vitro†

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Presentation transcript:

Effects of tirofiban on haemostatic activation in vitro† Tanaka K.A. , Katori N. , Szlam F. , Sato N. , Kelly A.B. , Levy J.H. British Journal of Anaesthesia Volume 93, Issue 2, Pages 263-269 (August 2004) DOI: 10.1093/bja/aeh193 Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 1 Effect of increasing concentration of tirofiban (TIRO) on thrombin generation in human platelet-rich plasma (PRP). Addition of increasing concentrations of tirofiban to PRP resulted in a significant prolongation of lag time, but not in a decrease in endogenous thrombin potential. British Journal of Anaesthesia 2004 93, 263-269DOI: (10.1093/bja/aeh193) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 2 Effect of increasing concentration of porcine heparin on thrombin generation in human platelet-rich plasma (PRP). Addition of increasing concentrations of heparin to PRP decreased both the lag time and the endogenous thrombin potential. British Journal of Anaesthesia 2004 93, 263-269DOI: (10.1093/bja/aeh193) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 3 Percentage aggregation of platelets with increasing concentrations of tirofiban (0, 7, 14, 35, 70 and 150 ng ml−1) after addition of ADP (20 μM). There was reduced aggregation with increasing concentrations of tirofiban. There was no significant difference in the reduction of aggregation between heparinized and citrated samples. British Journal of Anaesthesia 2004 93, 263-269DOI: (10.1093/bja/aeh193) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 4 Sonoclot signature tracing from an individual experiment. Baseline tracing indicates onset (s) and clot rate (gradient of the primary slope). The trend of slower onset and clot rate are shown with addition of either antithrombin (AT) or tirofiban (TIRO). British Journal of Anaesthesia 2004 93, 263-269DOI: (10.1093/bja/aeh193) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions

Fig 5 In vitro activating clotting time (ACT) responses (s) in blood samples from patients receiving heparin before surgery. Heparinization of the blood specimens to a final heparin concentration of 1.5, 2.5 and 4.1 U ml−1 resulted in significant prolongation of ACT in all groups (P<0.01 vs baseline). The addition of AT to heparinized blood samples slightly prolonged ACT, an effect that did not reach statistical significance when compared with heparin alone. The addition of tirofiban (TIRO) prolonged ACT at all heparin concentrations when compared with heparin only or heparin plus AT (*P<0.01 vs heparin only, †P<0.05 versus heparin plus AT). Data are mean (se). British Journal of Anaesthesia 2004 93, 263-269DOI: (10.1093/bja/aeh193) Copyright © 2004 British Journal of Anaesthesia Terms and Conditions