Cellular Immune Reconstitution and Its Impact on Clinical Outcome in Children with β Thalassemia Major Undergoing a Matched Related Myeloablative Allogeneic.

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Cellular Immune Reconstitution and Its Impact on Clinical Outcome in Children with β Thalassemia Major Undergoing a Matched Related Myeloablative Allogeneic Bone Marrow Transplant Reena Rajasekar, Vikram Mathews, Kavitha M. Lakshmi, Biju George, Auro Viswabandya, Mammen Chandy, Alok Srivastava Biology of Blood and Marrow Transplantation Volume 15, Issue 5, Pages 597-609 (May 2009) DOI: 10.1016/j.bbmt.2009.01.016 Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 1 Reconstitution kinetics of NK, B, T, and dendritic cell subsets in the first year post-SCT. Each line indicates corresponding cellular subsets at appropriate time points post-SCT. Error bars indicate the 25th to 75th percentiles values. Median pretransplant values are shown as a horizontal bar and the baseline error bars service as the reference range (highlighted area). MC, monocytoid dendritic cells; PC, plasmacytoid dendritic cells. Biology of Blood and Marrow Transplantation 2009 15, 597-609DOI: (10.1016/j.bbmt.2009.01.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 2 Overview of reconstitution kinetics of lymphocyte subsets and immune cells in the first year post-SCT. Each bar represents total WBC count, whereas lines indicate the corresponding cellular subsets at appropriate time points post-SCT (N = 63). (A) Illustrates reconstitution of total T cells (CD3), helper T cells (CD4), cytotoxic T cells (CD8), and natural killer (NK, CD3−CD56+CD16+). Post-HSCT recovery pattern of B cells (CD19), helper naïve T (CD4CD45RA), helper memory T (CD4CD45RO), cytotoxic naïve T (CD8CD45RA), and cytotoxic memory T (CD8CD45RO) cells are shown in (B), whereas cytokine-induced killer (CIK, CD3+CD56+CD16+) and dendritic cell recovery for both monocytoid (MC, Lin−HLADR−CD11C+) and plasmacytoid cells (PC, Lin−HLADR−CD123+) are depicted in (C). Biology of Blood and Marrow Transplantation 2009 15, 597-609DOI: (10.1016/j.bbmt.2009.01.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 3 Median day 28 NK cell counts and secondary graft rejection. Biology of Blood and Marrow Transplantation 2009 15, 597-609DOI: (10.1016/j.bbmt.2009.01.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions

Figure 4 Kaplan-Meier estimates of graft rejection, EFS, and OS by day 28 NK cell groups. (A) Secondary graft rejection. (B) EFS. Biology of Blood and Marrow Transplantation 2009 15, 597-609DOI: (10.1016/j.bbmt.2009.01.016) Copyright © 2009 American Society for Blood and Marrow Transplantation Terms and Conditions