Figure 1 Relationships between magnitude of antithrombotic benefit vs

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Date of download: 6/21/2016 Copyright © The American College of Cardiology. All rights reserved. From: Aspirin Therapy in Primary Cardiovascular Disease.

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Figure 1 Relationships between magnitude of antithrombotic benefit vs Figure 1 Relationships between magnitude of antithrombotic benefit vs. bleeding risk and cardiovascular risk in trials ... Figure 1 Relationships between magnitude of antithrombotic benefit vs. bleeding risk and cardiovascular risk in trials of aspirin for primary prevention. We fitted a univariate linear regression between the 10-year risk of major cardiovascular events (vascular death, non-fatal myocardial infarction, and non-fatal stroke) in the control group of each primary prevention trial included in the meta-analysis<sup>1</sup> (independent variable), and the percent absolute risk reduction for outcome events (major cardiovascular events, major bleeding, and major gastrointestinal bleeding) (dependent variable). The percent absolute risk reduction was calculated as: annual incidence in the control group − the annual incidence in the aspirin group × 100. We used the sample size of each trial as the weight (as in Ref.<sup>1</sup>). ARRIVE, Aspirin to Reduce Risk of Initial Vascular Events; ASCEND, A Study of Cardiovascular Events iN Diabetes; ASPREE, Aspirin in Reducing Events in the Elderly; BDT, British Doctors Trial; HOT, hypertension optimal treatment; JPAD, Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes; PHS, US Physicians Health Study; PPP, primary prevention project; TPT, thrombosis prevention trial; WHS, Women’s Health Study. Unless provided in the caption above, the following copyright applies to the content of this slide: Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2019. For permissions, please email: journals.permissions@oup.com.This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) Eur Heart J, ehz223, https://doi.org/10.1093/eurheartj/ehz223 The content of this slide may be subject to copyright: please see the slide notes for details.