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Volume 8, Issue 9, Pages 927-936 (September 2000) Observation of an unexpected third receptor molecule in the crystal structure of human interferon-γ receptor complex DJ Thiel, M-H le Du, RL Walter, A D’Arcy, C Chène, M Fountoulakis, G Garotta, FK Winkler, SE Ealick Structure Volume 8, Issue 9, Pages 927-936 (September 2000) DOI: 10.1016/S0969-2126(00)00184-2

Figure 1 Ribbon diagram of the 3:1 sIFN-γRα–IFN-γ complex. The complex is formed by combining the 2:1 complex with receptor R3. The IFN-γ dimer (I1 and I2) is shown in yellow; the R1 receptor is in red, the R2 receptor in blue, and the R3 receptor in green. The complex is oriented such that the normal axis to the cell membrane is approximately vertical. Structure 2000 8, 927-936DOI: (10.1016/S0969-2126(00)00184-2)

Figure 2 Structure of sIFN-γRα. (a) Stereoview Cα trace for sIFN-γRα with every tenth residue labeled. (b) Superposition of the three sIFN-γRα molecules. The superposition of the receptor molecules is based on the D2 domain only. Variations of the hinge angle between the D1 and D2 domains of each receptor is shown. The R1 receptor is in red, the R2 receptor in blue, and the R3 receptor in green. Structure 2000 8, 927-936DOI: (10.1016/S0969-2126(00)00184-2)

Figure 3 Electron density in the region of expected glycosylation. The final 2Fo–Fc map, contoured at 1.2σ, shows weak glycosylation density branching from Asn62 of the R2 receptor. Other potential glycosylation sites show similar electron density. Structure 2000 8, 927-936DOI: (10.1016/S0969-2126(00)00184-2)

Figure 4 Crystal contacts involving D2 receptor domains. (a) Receptor R3 is shown in green bridging receptor R1 (red) and a symmetry-related receptor R2′ (magenta). (b) Receptor R2 is shown in blue and an R2 receptor related by twofold symmetry (R2′) is shown in magenta. These interactions form the primary packing contacts in the crystals of the complex. Structure 2000 8, 927-936DOI: (10.1016/S0969-2126(00)00184-2)

Figure 5 The R3–R1 parallel β-sheet interface. The portion of the interface consisting of R1 residues is shown in red and that of R3 is in green. Key residues are labeled. Structure 2000 8, 927-936DOI: (10.1016/S0969-2126(00)00184-2)