Ventricular arrhythmias and myocardial inflammation: Long-term follow-up of patients with suspected myocarditis Valerie Pavlicek, Ingrid Kindermann,

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Presentation transcript:

Ventricular arrhythmias and myocardial inflammation: Long-term follow-up of patients with suspected myocarditis Valerie Pavlicek, Ingrid Kindermann, Jan Wintrich, Felix Mahfoud, Karin Klingel, Michael Böhm, Christian Ukena International Journal of Cardiology Volume 274, Pages 132-137 (January 2019) DOI: 10.1016/j.ijcard.2018.07.142 Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 1 Algorithm of initial evaluation and follow-up of patients with suspected myocarditis (CONSORT flow diagram). EMB: endomyocardial biopsy, MRI: magnetic resonance imaging, FU: follow-up. International Journal of Cardiology 2019 274, 132-137DOI: (10.1016/j.ijcard.2018.07.142) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 2 Histological and immunohistological patterns of EMB (A), probability of ICD implantation due to primary and secondary prevention (B), and probability of ICD implantation due to primary prevention (C) according to EMB results. Histological and immunohistological patterns of acute lymphocytic myocarditis (A–C), chronic lymphocytic myocarditis (D–F), dilated cardiomyopathy without inflammation (G–I). Bar = 30μm. From left to right column: Masson Trichrom stain, immunohistochemical stain for CD3 and MHCII+ (mainly macrophages). International Journal of Cardiology 2019 274, 132-137DOI: (10.1016/j.ijcard.2018.07.142) Copyright © 2018 Elsevier B.V. Terms and Conditions

Fig. 3 Probability of occurrence of ventricular arrhythmias requiring ICD therapy. International Journal of Cardiology 2019 274, 132-137DOI: (10.1016/j.ijcard.2018.07.142) Copyright © 2018 Elsevier B.V. Terms and Conditions