MIR-455-3P and HDACs co-regulate chondrogenesis

Slides:

Advertisements

Similar presentations

MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation G.

Advertisements

MicroRNA-92a-3p regulates the expression of cartilage-specific genes by directly targeting histone deacetylase 2 in chondrogenesis and degradation G.

Z. Zhang, Y. Kang, Z. Zhang, H. Zhang, X. Duan, J. Liu, X. Li, W. Liao

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

Fully-automated cartilage segmentation from magnetic resonance images of the knee using atlas and graph-cut algorithms J.-G. Lee, S. Gumus, K.C. Kwoh,

S. Gavard Osteoarthritis and Cartilage

In vitro cell surface markers are insufficient to identify in vivo/in situ multipotent synovial mesenchymal stem cells isolated from normal or osteoarthritic.

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

S. Kashyap, H. Zhang, M. Sonka Osteoarthritis and Cartilage

Synovial pathology detected on ultrasound correlates with the severity of radiographic knee osteoarthritis more than with symptoms M. Hall, S. Doherty,

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative M.A. Bowes, C.B. Wolstenholme,

Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Role of endothelin-1 in endochondral ossification and osteoarthritis

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Mechanical response of articular cartilage damaged by macro cracks

High flexion is associated with knee osteoarthritis - of four high flexion postures, flat foot squatting minimizes knee adduction moments H.C. Chong,

Z. Zhang, W. Liao, Z. Zhang, X. Duan, C. Hou

The differences on extracellular matrix among each portion of meniscus

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

Damage to The Extracellular Matrix (ECM) in Articular Cartilage is Observed via Changes in The T2–T2 Exchange Rates Between Fluid in The Pore Space and.

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

H. J. Nieminen, T. Ylitalo, S. Kauppinen, E. Hæggström, M. Finnilä, S

Association of ultrasound-defined structural changes with regional and diffuse knee pain patterns – Oulu Knee Osteoarthritis study J. Podlipská, P. Kaukinen,

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

The influence of early osteoarthritic collagen network de-structuring in articular cartilage on the tissue stiffness and swelling properties M. Nickien,

Osteoarthritis and Cartilage

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

Coordinate and synergistic effects of extensive treadmill exercise and ovariectomy on articular cartilage degeneration K. Miyatake, K. Tsuji, J. Yamada,

N. Segal, E. Frick, M. Nevitt, J. Torner, D. Felson, A. Guermazi, D

D.D. Anderson, A.M. Kern, T.J. Stockman, C.M. Findlay, N.A. Segal

Structural Damage of the Thumb Base in Patients With Hand Osteoarthritis, Assessment by Magnetic Resonance Imaging Compared to Standard Radiography S.

Patellofemoral Bone Morphology is Related to Gender But Not Pain: 3D Quantitative Data Analysis From The OAI M.A. Bowes, B.T. Drew, A.C. Redmond, B.

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Knocking out or pharmaceutical inhibition of fatty acid binding protein 4 (Fabp-4) alleviates osteoarthritis induced by a very high fat diet in mouse

Early intervention to prevent cartilage degeneration by administration of anti-vegf antibody in rabbit model T. Nagai, M. Sato, T. Kutsuna, T. Ukai,

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

A peptide temporally enhanced chondrogenesis of mesenchymal stem cells

3D-histopathological grading of articular cartilage using contrast-enhanced high- resolution micro-CT H. Gahunia, S. Karhula, T. Ylitalo, E. Hæggström,

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

A.B. Lovati, A. Pozzi, M. Bongio, C. Recordati, G. Berzero, M. Moretti

T2 and T1rho values of grade 1 early degenerative cartilage in the distal femur using angle/layer dependent approach Y. Kaneko, T. Nozaki, H. Yu, K.

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

3D modelling of the hip joint from clinical imaging data

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Osteoarthritis year 2012 in review: biology

Hip derived synovial mesenchymal progenitor cell surface markers as indicators for differentiation potential A. Affan, N. Al-Jezani, P. Railton, J. Powell,

J.H. Ylärinne, C. Qu, M.J. Lammi Osteoarthritis and Cartilage

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Amyloid micronetworks for cartilage repair

Ex vivo and in vivo magnetic resonance imaging of cartilage canals in swine at predilection sites of osteochondrosis F. Toth, M.J. Nissi, J. Zhang, S.

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

In situ evaluation of chondrofix® osteochondral allograft 25 months following implantation: A case report K.L. Reynolds, S.K. Bishai Osteoarthritis.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

High resolution T1ρ mapping of human knee cartilage at 7T

Osteoarthritis year in review 2016: mechanics

M. Doherty, P. Dieppe Osteoarthritis and Cartilage

Fully automated segmentation of cartilage from magnetic resonance images using improved 3D shape context and active shape model T. Ye, X. Cui, H. Kim

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

MIR-455-3P and HDACs co-regulate chondrogenesis Z. Zhang, W. Chen, Z. Zhang, Y. Kang, Y. Kang, W. Liao Osteoarthritis and Cartilage Volume 24, Pages S224-S225 (April 2016) DOI: 10.1016/j.joca.2016.01.431 Copyright © 2016 Terms and Conditions

Fig. 1. Exemplary μCT images of osteochondral plugs (left) with different degeneration (normal/mild/ moderate/severe) and adjacent tissue (right) (spacing indicated between the slices in μm). Pathologically most important features have been highlighted with yellow letters. The μCT grade ranges from 0 (normal) to 44 (extremely severe). μCT was capable of providing a sufficient contrast and resolution to permit 3D- histopathological grading of human osteochondral samples. Osteoarthritis and Cartilage 2016 24, S224-S225DOI: (10.1016/j.joca.2016.01.431) Copyright © 2016 Terms and Conditions

Figure 2 ChIP-qPCR: Col2a1 promoter. Osteoarthritis and Cartilage 2016 24, S224-S225DOI: (10.1016/j.joca.2016.01.431) Copyright © 2016 Terms and Conditions