Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome

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Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome Fabio Martinon Immunity Volume 36, Issue 3, Pages 313-315 (March 2012) DOI: 10.1016/j.immuni.2012.03.005 Copyright © 2012 Elsevier Inc. Terms and Conditions

Figure 1 Model of NLRP3 Inflammasome Assembly and Activation NLRP3 inflammasome activators such as extracellular ATP and nigericin trigger potassium efflux, loss of mitochondrial membrane potential, and mitochondrial ROS production. These events result in the oxidation of mitochondrial DNA and its release into the cytosol. Binding of oxidized DNA to NLRP3 promotes assembly and oligomerization of the inflammasome. The recruitment of the adaptor ASC and the enzyme caspase-1 to the inflammasome are crucial for its pro-IL-1β and pro-IL-18 cleaving activity. Immunity 2012 36, 313-315DOI: (10.1016/j.immuni.2012.03.005) Copyright © 2012 Elsevier Inc. Terms and Conditions