Figure 1 Illustration of white matter– and lesion-associated regions of interest (ROIs)‏ Illustration of white matter– and lesion-associated regions of.

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Figure 1 Illustration of white matter– and lesion-associated regions of interest (ROIs)‏ Illustration of white matter– and lesion-associated regions of interest (ROIs) The images are from a 25-year-old female patient with relapsing-remitting MS and an Expanded Disability Status Scale score of 1.0. (A) Axial view of gadolinium-enhanced 3DT1 MRI showing T1-hypointense white matter lesions. (B) Respective MRI with overlaid ROIs of T1-hypointense lesions (red), perilesional areas with 0-3 mm (brown) and 3-6 mm (yellow) radiuses, and normal-appearing white matter (green). Note that some of the perilesional ROIs visible in this slice are not associated with T1-hypointense lesions, but are due to larger perilesional ROIs associated with T1-hypointense lesion cores in adjacent sections. The gray matter areas have been masked out from all the lesion-associated ROIs for all analyses. Eero Rissanen et al. Neurol Neuroimmunol Neuroinflamm 2018;5:e443 Copyright © 2018 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Academy of Neurology