Infection with a respiratory virus before hematopoietic cell transplantation is associated with alloimmune-mediated lung syndromes Birgitta Versluys,

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Presentation transcript:

Infection with a respiratory virus before hematopoietic cell transplantation is associated with alloimmune-mediated lung syndromes Birgitta Versluys, MD, Marc Bierings, MD, Jean Luc Murk, MD, Tom Wolfs, MD, Caroline Lindemans, MD, Kors vd Ent, MD, Jaap Jan Boelens, MD Journal of Allergy and Clinical Immunology Volume 141, Issue 2, Pages 697-703.e8 (February 2018) DOI: 10.1016/j.jaci.2017.03.055 Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Journal of Allergy and Clinical Immunology 2018 141, 697-703 Journal of Allergy and Clinical Immunology 2018 141, 697-703.e8DOI: (10.1016/j.jaci.2017.03.055) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 A, Cumulative incidence of allo-LSs for patients with negative RV results, positive BAL fluid RV results, and positive NPA-only RV results. B, Cumulative incidence of allo-LSs for patients with negative RV results and both those with and those without rhinovirus (from BAL fluid only, without taking NPA results into account). Journal of Allergy and Clinical Immunology 2018 141, 697-703.e8DOI: (10.1016/j.jaci.2017.03.055) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Cumulative incidence of allo-LSs in patients with positive BAL fluid RV results according to the presence of grade II to IV aGVHD in another organ. Journal of Allergy and Clinical Immunology 2018 141, 697-703.e8DOI: (10.1016/j.jaci.2017.03.055) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 A, Probability of TRM for patients with and without allo-LSs. B, Probability of overall survival (OS) for patients with and without allo-LSs. Journal of Allergy and Clinical Immunology 2018 141, 697-703.e8DOI: (10.1016/j.jaci.2017.03.055) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 A, Cumulative incidence of BOS according to sex. B, Cumulative incidence of BOS according to positive BAL fluid RV results. Journal of Allergy and Clinical Immunology 2018 141, 697-703.e8DOI: (10.1016/j.jaci.2017.03.055) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 A, Cumulative incidence of IPS according to positive BAL fluid RV results. B, Cumulative incidence of IPS according to diagnosis. Journal of Allergy and Clinical Immunology 2018 141, 697-703.e8DOI: (10.1016/j.jaci.2017.03.055) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Cumulative incidence of allo-LSs according to RV viral load in BAL fluid (defined as greater or lower than the median Ct value [32] for RV). Journal of Allergy and Clinical Immunology 2018 141, 697-703.e8DOI: (10.1016/j.jaci.2017.03.055) Copyright © 2017 American Academy of Allergy, Asthma & Immunology Terms and Conditions