M-MDSCs and their supernates decreased B cell metabolism.

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M-MDSCs and their supernates decreased B cell metabolism. M-MDSCs and their supernates decreased B cell metabolism. (A) Cell energy phenotype of B cells stimulated with LPS in the presence of supernates derived from suppressive cultures of MDSCs and B cells. (B) Quantification of ECAR and (C) OCR. (D) 2-NBDG (fluorescent glucose analog) uptake by B cells stimulated with LPS in the presence or absence of M-MDSCs. Data shown in (A)–(D) are from a representative experiment, with a similar pattern of results observed in three experiments. *p < 0.05, **p < 0.01, ***p < 0.001. Jessica L. Rastad, and William R. Green ImmunoHorizons 2018;2:87-106 Copyright © 2018 The Authors