Mitochondria and Cancer

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Presentation transcript:

Mitochondria and Cancer Wei-Xing Zong, Joshua D. Rabinowitz, Eileen White Molecular Cell Volume 61, Issue 5, Pages 667-676 (March 2016) DOI: 10.1016/j.molcel.2016.02.011 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Mitochondria as Biosynthetic and Signaling Hubs The TCA cycle uses substrates from glycolysis, fatty acid oxidation, and amino acid catabolism to generate building blocks and high-energy electrons (NADH and FADH2) to power the ETC. Major biosynthetic products produced by mitochondria and signaling pathways regulated by mitochondrial function are indicated. Molecular Cell 2016 61, 667-676DOI: (10.1016/j.molcel.2016.02.011) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Characteristics of Oncocytic Tumors with Functional versus Defective Mitochondria Molecular Cell 2016 61, 667-676DOI: (10.1016/j.molcel.2016.02.011) Copyright © 2016 Elsevier Inc. Terms and Conditions