Figure 1 The occurrence of maternal cardiovascular events for the different diagnosis groups. AOP, aortic pathology; ... Figure 1 The occurrence of maternal.

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Figure 1 The occurrence of maternal cardiovascular events for the different diagnosis groups. AOP, aortic pathology; ... Figure 1 The occurrence of maternal cardiovascular events for the different diagnosis groups. AOP, aortic pathology; CMP, cardiomyopathy; CONHD, congenital heart disease; IHD, ischemic heart disease; PAH, pulmonary arterial hypertension; VHD, valvular heart disease. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Eur Heart J, ehz136, https://doi.org/10.1093/eurheartj/ehz136 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 2 Univariable and multivariable logistic regression analysis for the primary endpoint or heart failure. All ... Figure 2 Univariable and multivariable logistic regression analysis for the primary endpoint or heart failure. All variables used in this regression were pre-pregnancy characteristics. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Eur Heart J, ehz136, https://doi.org/10.1093/eurheartj/ehz136 The content of this slide may be subject to copyright: please see the slide notes for details.

Figure 3 The trends over time in death or heart failure, for the overall cohort and for the three largest diagnosis ... Figure 3 The trends over time in death or heart failure, for the overall cohort and for the three largest diagnosis groups. The number of total included pregnancies and the percentage inclusion of mWHO class IV in the corresponding year are shown below the figures, in total as well as for the diagnosis groups. The data points represent the number of death and/or heart failure per year. Time trends were analysed by linear mixed effect models with the logit link function (see Methods section). The model that we fitted for the overall cohort was as follows: logit (endpoint) = −2.447 + 0.524 × τ – 0.130 × t<sup>2</sup> + 0.008 × t<sup>3</sup>, with t = time since 1 January 2007. The significance of the respective regression coefficients was as follows: <0.001, 0.003, 0.002, 0.002. , Cardiomyopathy; , Valvular heart disease; , Overall cohort; , Congenital heart disease. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Eur Heart J, ehz136, https://doi.org/10.1093/eurheartj/ehz136 The content of this slide may be subject to copyright: please see the slide notes for details.

Take home figure From 2007 to 2018, pregnant women with heart disease were included in the Registry Of Pregnancy And Cardiac ... Take home figure From 2007 to 2018, pregnant women with heart disease were included in the Registry Of Pregnancy And Cardiac disease (ROPAC). During that time, the incidence of ‘maternal death or heart failure’ dropped, despite the inclusion of more seriously ill women (mWHO IV). Especially women with cardiomyopathies or pulmonary arterial hypertension were at risk of ‘maternal death or heart failure’. Pre-pregnancy risk factors were signs of heart failure prior to pregnancy, NYHA class > II, systemic ventricular ejection fraction of below 40%, mWHO class IV conditions and anticoagulation use. Unless provided in the caption above, the following copyright applies to the content of this slide: © The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Cardiology.This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com Eur Heart J, ehz136, https://doi.org/10.1093/eurheartj/ehz136 The content of this slide may be subject to copyright: please see the slide notes for details.