Decline in antibiotic resistance and changes in the serotype distribution of Streptococcus pneumoniae isolates from children with acute otitis media;

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Decline in antibiotic resistance and changes in the serotype distribution of Streptococcus pneumoniae isolates from children with acute otitis media; a 2001–2011 survey by the French Pneumococcal Network M. Kempf, E. Varon, A. Lepoutre, A. Gravet, R. Baraduc, M. Brun, H. Chardon, J. Cremniter, J. Croizé, F. Dalmay, M.-C. Demachy, T. Fosse, C. Grelaud, T. Hadou, F. Hamdad, J.-L. Koeck, S. Luce, S. Mermond, I. Patry, A. Péchinot, J. Raymond, A. Ros, C. Segonds, B. Soullié, D. Tandé, M. Vergnaud, V. Vernet-Garnier, F. Wallet, L. Gutmann, M.-C. Ploy, P. Lanotte Clinical Microbiology and Infection Volume 21, Issue 1, Pages 35-42 (January 2015) DOI: 10.1016/j.cmi.2014.08.009 Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Trends in Streptococcus pneumoniae serotypes isolated from middle ear fluid of French children with acute otitis media between 2001 and 2011. Clinical Microbiology and Infection 2015 21, 35-42DOI: (10.1016/j.cmi.2014.08.009) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Trends in the serotype distribution of Streptococcus pneumoniae isolated from middle ear fluid of French children with acute otitis media, according to their susceptibility to penicillin G. The colour scale highlights the penicillin minimum inhibitory concentration. Serotypes are sorted, from left to right, according to their inclusion in PCV-7 and PCV-13, and their non-inclusion in either vaccine. Each graph represents one year (a, 2001; b, 2003; c, 2005; d, 2007; e, 2009; f, 2011). Clinical Microbiology and Infection 2015 21, 35-42DOI: (10.1016/j.cmi.2014.08.009) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Trends in the serotype distribution of Streptococcus pneumoniae isolated from middle ear fluid of French children with acute otitis media, according to their susceptibility to penicillin G. The colour scale highlights the penicillin minimum inhibitory concentration. Serotypes are sorted, from left to right, according to their inclusion in PCV-7 and PCV-13, and their non-inclusion in either vaccine. Each graph represents one year (a, 2001; b, 2003; c, 2005; d, 2007; e, 2009; f, 2011). Clinical Microbiology and Infection 2015 21, 35-42DOI: (10.1016/j.cmi.2014.08.009) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions