Serum LAMC2 levels in pancreatic adenocarcinoma (PDAC) and other samples from Japan. Serum LAMC2 levels in pancreatic adenocarcinoma (PDAC) and other samples.

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Raphael Sandaltzopoulos, PhD, MBA Professor at MBG (Molecular Biology) Lab. of Gene Expression, Molecular Diagnosis and Modern Therapeutics,

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European Urology Focus

binding sites 58 of the 473 unambiguously assigned phosphorylation sites are predicted by Scansite to be sites for binding. 50 of these correspond.

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Serum LAMC2 levels in pancreatic adenocarcinoma (PDAC) and other samples from Japan. Serum LAMC2 levels in pancreatic adenocarcinoma (PDAC) and other samples from Japan.A, Scatter plot of serum LAMC2 and CA19.9 concentrations determined in normal (healthy) (n = 50), benign disease (n = 50), and PDAC (n = 50) serum samples obtained from Hamamatsu University School of Medicine, Japan (for more details on the samples see Table I). The PDAC samples were not stage-classified. The horizontal lines represent median concentrations and the dotted lines are cut-off values for LAMC2 (150 ng/ml) and CA19.9 (37 U/ml). p Values were calculated by Mann-Whitney U tests. B, The sensitivity of CA19.9, LAMC2, and both in the diagnosis of PDAC and the proportion of patients tested positive for LAMC2 and their corresponding CA19.9 status (positive and negative). C, Receiver operating characteristic (ROC) curves for CA19.9, LAMC2, and both for patients with PDAC versus benign samples. AUC, area under the curve. The combined assessment of CA19.9 and LAMC2 surpassed the individual diagnostic ability of either of the two markers (p = 0.035). Hari Kosanam et al. Mol Cell Proteomics 2013;12:2820-2832 © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.