A Dynamic Biochemomechanical Model of Geometry-Confined Cell Spreading

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Presentation transcript:

A Dynamic Biochemomechanical Model of Geometry-Confined Cell Spreading Zi-Long Zhao, Zong-Yuan Liu, Jing Du, Guang-Kui Xu, Xi-Qiao Feng Biophysical Journal Volume 112, Issue 11, Pages 2377-2386 (June 2017) DOI: 10.1016/j.bpj.2017.04.044 Copyright © 2017 Biophysical Society Terms and Conditions

Figure 1 (A) Schematic of a cell spreading in a microchamber. (B) Top view of the cell in (A). The forces acting on the microtubule-membrane joints are illustrated. To see this figure in color, go online. Biophysical Journal 2017 112, 2377-2386DOI: (10.1016/j.bpj.2017.04.044) Copyright © 2017 Biophysical Society Terms and Conditions

Figure 2 Evolution of the contact areas of cells spreading in chambers of defined geometry: (A) rectangle, (B) ellipse, (C) triangle, (D) isosceles trapezoid, (E) right trapezoid, and (F) L-shape. To see this figure in color, go online. Biophysical Journal 2017 112, 2377-2386DOI: (10.1016/j.bpj.2017.04.044) Copyright © 2017 Biophysical Society Terms and Conditions

Figure 3 Steady-state configurations and angular distributions of microtubule pulling forces for cells spreading in chambers of defined geometry: (A) rectangle, (B) ellipse, (C) triangle, (D) isosceles trapezoid, (E) right trapezoid, and (F) L-shape. To see this figure in color, go online. Biophysical Journal 2017 112, 2377-2386DOI: (10.1016/j.bpj.2017.04.044) Copyright © 2017 Biophysical Society Terms and Conditions

Figure 4 Influences of the initial deviation of the cellular position on spreading behavior. (A and B) Area-time relation (A) and angular distribution (B) of microtubule forces in a cell spreading in a rectangular chamber. (C and D) Area-time relation (C) and angular distribution (D) of microtubule forces in a cell spreading in an L-shaped chamber. To see this figure in color, go online. Biophysical Journal 2017 112, 2377-2386DOI: (10.1016/j.bpj.2017.04.044) Copyright © 2017 Biophysical Society Terms and Conditions

Figure 5 (A) Area, S¯, of the spreading cells as a function of time, t, where the circles and squares represent experimental data. (B–D) Effects of the adhesive bond density, Nb (B), the membrane tension, γ (C), and the microtubule number, n (D), on the S¯-t relation. To see this figure in color, go online. Biophysical Journal 2017 112, 2377-2386DOI: (10.1016/j.bpj.2017.04.044) Copyright © 2017 Biophysical Society Terms and Conditions