a) Schematic example of a basket trial.

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Presentation transcript:

a) Schematic example of a basket trial. a) Schematic example of a basket trial. These trials are often viewed as parallel, phase II trials for one drug, but within the same legal entity on the basis of a common denominator that can be molecular alteration(s). Most basket trials are histology-independent and aberration-specific clinical trials if a predictive marker is used. These trials are usually tested locally and often fall into the “trial to learn” category. b) Schematic illustration of the Vemurafenib basket trial [10]. NSCLC: nonsmall cell lung cancer. Images courtesy of Gustave Roussy Cancer Campus Grand Paris, Villejuif, France. Jessica Menis et al. Eur Respir Rev 2014;23:367-378 ©2014 by European Respiratory Society