T-705 treatment of SFTSV-infected IFNAR−/− mice through oral administration. T-705 treatment of SFTSV-infected IFNAR−/− mice through oral administration.

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T-705 treatment of SFTSV-infected IFNAR−/− mice through oral administration. T-705 treatment of SFTSV-infected IFNAR−/− mice through oral administration. (A) Six or seven female mice in each group were inoculated s.c. with 1.0 × 106 TCID50 of SFTSV (SPL010). Mice were treated with T-705 at a dose of 60 or 300 mg/kg/day. The drug was administered once daily p.o. using a stomach probe. Placebo mice received 2.9% sodium bicarbonate solution as a solvent for T-705. T-705 was administered for 5 days as indicated in the upper columns (shaded in gray with the survival curves). Survival was determined using Kaplan-Meier analysis and GraphPad Prism6. **, P < 0.01 compared with the results of the placebo group. Relative weight is shown as means with standard deviations. (B and C) Histopathological and immunohistochemical examinations of the tissues collected from the SFTSV-infected IFNAR−/− mice treated with T-705 or left untreated. Tissues were collected from mice at 4 days postinfection (untreated mice) or at 12 days postinfection (T-705-treated mice). (B) Low-power views of the cervical lymph node and the spleen. Bars, 500 µm. The arrow (upper left) indicates necrosis; blask asterisks indicate intact structures; red asterisks indicate necrosis. (C) Histopathology and immunohistochemical analyses of cervical lymph nodes, spleens, livers, and kidneys. Bars, 100 µm. H&E, hematoxylin-and-eosin staining; VA, viral antigens detected by immunohistochemistry. Hideki Tani et al. mSphere 2016; doi:10.1128/mSphere.00061-15