Distribution of informative SNPs with LOH (black bars) on each chromosome (rows, oriented p-arm at the bottom and q-arm at the top of each chromosome)

Slides:

Advertisements

Similar presentations

Homozygous deletions within chromosome 9q23.

Advertisements

IL-1β differentially regulates CXCL5 and CXCL8 protein secretion in NHTBE and NSCLC cells. IL-1β differentially regulates CXCL5 and CXCL8 protein secretion.

Sample Column Chart- No Data Labels, no lines SOURCE:

EP4 promoter activity is induced by sulindac sulfide in T98G cells.

Obesity and type 2 diabetes forecasts.

Quantitative PCR of CRTAC1 (white columns) and WASF1 (black columns) loci in germ line DNA (A), glomus tumor no. 1 (B), and glomus tumor no. 3 (C) from.

Prevalence of depression severity according to the stage of diabetic nephropathy. Prevalence of depression severity according to the stage of diabetic.

ROC curve for separating advanced stages (advanced BE and EA) versus early stages (BE or BE instability) using total genome-wide LOH [area under the curve.

Number of 0.5-Mb windows with chromosome lesions that reached statistical significance across patients in early (BE early and BE instability) and late.

A, genomic copy number profiles of chromosome 8 with array CGH in SUM-44, -52, and A, genomic copy number profiles of chromosome 8 with array CGH.

Expression changes of specific epigenetic-controlled tumor-related genes by the prenatal/maternal BSp treatment. qRT-PCR and Western blot analysis were.

Distribution of protrusive activity.

Cancer mutations in enriched RBP motifs.

Pleiotropic Effects of Trait-Associated Genetic Variation on DNA Methylation: Utility for Refining GWAS Loci Eilis Hannon, Mike Weedon, Nicholas Bray,

Changes in the ratio of (EPA+DHA):AA in the breast triacylglyceride compartment. Changes in the ratio of (EPA+DHA):AA in the breast triacylglyceride compartment.

SW fraction induces S phase arrest and apoptosis.

Interactive morphogenesis in Ch-CNC droplets laden with magnetic NPs

Quarterly hospitalizations of patients diagnosed with primary TB (top) or primary TB and secondary diabetes (bottom) in the USA (NIS, 1998–2011). *Not.

Peripheral CAF model. Peripheral CAF model. A, bright field (top) and fluorescence (bottom) micrographs of aggregates that contain RFP-tagged 344SQ cells.

PD-L1 expression by DC subsets from lesional CTCL and healthy skin.

Dietary plant extracts inhibit NF-κB activation in vitro.

Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC region. Scatterplot and LD map of the genotyped tagging SNPs along the TOX3/LOC

Diagnostic performance of dentist clinical impression.

Socially isolated SV40 Tag mice develop significantly larger mammary gland tumors. Socially isolated SV40 Tag mice develop significantly larger mammary.

Frequent alterations identified and potential actionability.

X-tile analysis of survival data from the SEER registry reveals a continuous distribution based on tumor size and node number, and a U-shaped distribution.

Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.

A, effect of IP6 feeding on the weight of LUT organs normalized to body weight. A, effect of IP6 feeding on the weight of LUT organs normalized to body.

Case study showing significant epidural fat contraction after weight loss. Case study showing significant epidural fat contraction after weight loss. The.

Inhibitory effect of different doses of IP6 on prostate tumor progression in TRAMP mice. Inhibitory effect of different doses of IP6 on prostate tumor.

Effect of nicotinamide and carbogen on 5-FU uptake (measured as SUV3

Correlation between serum visfatin concentrations and the clinical stage (A) and tumor size (B, C) of HCCs. A and B, the correlations were determined by.

A and B, images from a patient with an invasive carcinoma on the floor of the mouth. A and B, images from a patient with an invasive carcinoma on the floor.

Dose-dependent effect of IP6 feeding on molecules associated with tumor sustenance and glucose transportation in dorsolateral prostate of TRAMP mice. Dose-dependent.

Predictive value of the FGFR3 mutation assay increases with multiple consecutive FGFR3-positive urine samples. Predictive value of the FGFR3 mutation assay.

FGFR3 mutation analysis of a selection of urine samples from patients included with an FGFR3-mutant (MT) tumor. FGFR3 mutation analysis of a selection.

Visualization of prescriptive algorithm: provider dashboard prototype.

EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.

Regional association plot of genotyped and imputed SNPs in proximity to rs , summarizing evidence of interaction with at least weekly heartburn or.

Overview of TIMER modules on the website.

Immune responses to 12MP and 6MHP.

A, unsupervised clustering of all BRCA1 (red), BRCA2 (blue), and sporadic (green) breast tumors of our collection using the regions reported as discriminative.

A and B, mRNA expression relative to ERα (in%) for ZNF423 (A) and BRCA1 (B) for LCLs of known genotypes for variant (V) and WT chromosome 16 ZNF423 SNPs.

Specific DNA methylation and expression signatures associated with binding of E2A–PBX1 fusion protein. Specific DNA methylation and expression signatures.

Cocultivation of fibroblasts with epithelial cells (EP156T-luc).

Survival risk prediction analysis and application of the metastasis gene signature. Survival risk prediction analysis and application of the metastasis.

HMQ1611 inhibited breast tumor growth in mice.

Representative images demonstrating LOH in breast cancer patients’ paired BM aspirate and primary tumors (T) at D14S62, D14S51, and D8S321, respectively.

The long tail of mutational hotspots in cancer.

Histology (H&E; original magnification, ×100 for B-2P/C-12P/C-64P and ×40 for C-10P; top) of small-sized lung adenocarcinomas and immunohistochemical staining.

Genomic determinants of response to cytotoxic chemotherapy.

AS1411 alters subcellular distribution of PRMT5 in a time-dependent, dose-dependent, and nucleolin-dependent manner. AS1411 alters subcellular distribution.

A summary of the average level of methylation of selected MCA/RDA MICPs by bisulfite-modified genomic sequencing. A summary of the average level of methylation.

Antigen expression and Breslow thickness.

Single nucleotide polymorphism array analysis can distinguish different genetic mechanisms that lead to loss of heterozygosity (LOH). Single nucleotide.

A, LOH on chromosome 17q (D17S785; expected size, 181–207 bp) in SC-IDC (Lane 2), SC-DCIS (Lane 3), clear-cut normal epithelial cells (Lane 4), DCIS (Lane.

A, Proportion for different in silico predictions at the RNA level.

Regression analysis showing the positive correlation between number of months since the prior chemotherapy regimen (X axis) and the difference between.

Effect of dexamethasone on PCDGF/GP88 mRNA and protein expressions and effect of PCDGF/GP88 on dexamethasone-induced cell death. Effect of dexamethasone.

Effect of BCAA on the progression of cell cycle, expression of p21CIP1, and induction of apoptosis in HepG2 cells in the presence and absence of visfatin.

Representative images for different populations of detected cells in prostate cancer patients and five rounds of FISH in a CTC. A, Immunofluorescence image.

A, Changes in BRAFV600E cfDNA allele fraction from baseline after one dose of treatment for 12 patients with serial samples available, classified according.

Quantile–quantile plots of 42 interaction P values for seven SNPs under investigation. Quantile–quantile plots of 42 interaction P values for seven SNPs.

Gene expression heatmap of non–T-cell-inflamed, intermediate, and T-cell–inflamed testicular germ cell tumors from TCGA. Genes are on the row, and samples.

AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. A,

Integrated analysis of gene expression and copy number alterations.

Epithelial and stromal percentage clusterin staining in normal nonadjacent colonic tissue and matched tumor tissue in 202 patients with stage II colorectal.

A. A. Partial 6p ideogram with a contig of BAC/P1 clones used to generate region-specific array. Each bar represents a BAC/PAC clone. B. A representative.

CONSORT diagram. a, 5 had a major treatment violation (3 refused and 2 received wrong treatment) but were included in the analyses; b, 4 had a major treatment.

GSN and DNMT1 expression are inversely correlated in a pattern associated with patient survival. GSN and DNMT1 expression are inversely correlated in a.

Presentation transcript:

Distribution of informative SNPs with LOH (black bars) on each chromosome (rows, oriented p-arm at the bottom and q-arm at the top of each chromosome) in individual samples from 42 patients (columns). Distribution of informative SNPs with LOH (black bars) on each chromosome (rows, oriented p-arm at the bottom and q-arm at the top of each chromosome) in individual samples from 42 patients (columns). Regions with no black bars represent either noninformative SNPs or no LOH. Patients are grouped along the X axis into the four stages of neoplastic progression and the numbers along the X axis refer to individual patients. A, chromosomes 1 to 5; B, chromosomes 6 to 12; C, chromosomes 13 to 22. Xiaohong Li et al. Cancer Prev Res 2008;1:413-423 ©2008 by American Association for Cancer Research