Inhibitory effect of T-705, ribavirin, T-1105, and T-1106 on SFTSV replication in Vero cells. Inhibitory effect of T-705, ribavirin, T-1105, and T-1106.

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Inhibitory effect of T-705, ribavirin, T-1105, and T-1106 on SFTSV replication in Vero cells. Inhibitory effect of T-705, ribavirin, T-1105, and T-1106 on SFTSV replication in Vero cells. (A) Vero cells were pretreated with various concentrations of T-705, ribavirin, T-1105, and T-1106 4 h before infection and were inoculated with SFTSV (SPL010) at an MOI of 0.1. (B) Vero cells were pretreated with various concentrations of T-705 and infected with HB29, YG1, SPL010, or SPL087 strains of SFTSV at an MOI of 0.1. The virus infectious dose in the culture supernatants and cell growth and viability after treatment with each compound are shown. A sigmoidal dose-response curve was fitted to the data using GraphPad Prism6 (GraphPad Software). Hideki Tani et al. mSphere 2016; doi:10.1128/mSphere.00061-15