A Butterfly Effect on Neural Stem Cells

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A Butterfly Effect on Neural Stem Cells Pierre Vanderhaeghen Neuron Volume 93, Issue 4, Pages 720-722 (February 2017) DOI: 10.1016/j.neuron.2017.02.015 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The Spindle Pole Orientation in Embryonic Progenitors Has a Long-Lasting Influence on the Adult Neural Stem Cell Pool The embryonic lateral ganglionic eminence (LGE) contains a diverse array of progenitors, including radial glial cells (RGC, in blue) and small neural progenitors (SNP, in green), characterized by specific morphology and patterns of cell division. Adult neural stem cells (aNSC, in orange) residing in the adult subependymal zone (SEZ) emerge from LGE RGC. Time-specific overexpression of Inscuteable (Insc OE) or loss of function of LGN (dNLGN) in embryonic RGC results in misorentation of mitotic spindle and changes in patterns of division, which leads ultimately to a reduction in the pool of aNSC in adulthood. See text for further explanatory details. Neuron 2017 93, 720-722DOI: (10.1016/j.neuron.2017.02.015) Copyright © 2017 Elsevier Inc. Terms and Conditions