Berger JS, et al. JAMA 2009;301:1909-19.

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Berger JS, et al. JAMA 2009;301:1909-19

Flow Diagram of the Literature Search and Trial Selection Process Berger JS, et al. JAMA 2009;301:1909-19

Design of Trials Included in the Meta-analysis - Part I Berger JS, et al. JAMA 2009;301:1909-19

Design of Trials Included in the Meta-analysis - Part II Berger JS, et al. JAMA 2009;301:1909-19

Effect of Any Aspirin on the Prevention of Composite Cardiovascular End Points Berger JS, et al. JAMA 2009;301:1909-19

Effect of Any Aspirin on the Prevention of Nonfatal Myocardial Infarction, Nonfatal Stroke, and Cardiovascular Death Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured. a - Pooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval. Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured. aPooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval. Berger JS, et al. JAMA 2009;301:1909-19

Effect of Any Aspirin on the Prevention of Any Death and Major Bleed Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured. aPooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval. Berger JS, et al. JAMA 2009;301:1909-19

Effect of Aspirin Monotherapy on the Prevention of Adverse Outcomes Major cardiovascular events defined as the composite of nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured. a - Pooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval. Major cardiovascular events defined as the composite of nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. Zero weight denotes a study in which there were no occurrences of the indicated event. A blank row denotes a study in which the indicated event was not measured. aPooled relative risks (RRs) are from a random-effects model. CI indicates confidence interval. Berger JS, et al. JAMA 2009;301:1909-19