Select: Molecular Pathology of Alzheimer's Disease

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Presentation transcript:

Select: Molecular Pathology of Alzheimer's Disease Cell Volume 144, Issue 3, (February 2011) DOI: 10.1016/j.cell.2011.01.027 Copyright © 2011 Terms and Conditions

β-amyloid induces AMPA receptor (AMPAr) dephosphorylation via a pathway involving caspase-3 (Casp-3) and calcineurin (CaN). Image courtesy of F. Cecconi. Cell 2011 144, DOI: (10.1016/j.cell.2011.01.027) Copyright © 2011 Terms and Conditions

Tau proteins do not normally go to dendritic spines (red spines, triangles) but are mislocalized under disease conditions (yellow spines, arrows). Image courtesy of D. Liao. Cell 2011 144, DOI: (10.1016/j.cell.2011.01.027) Copyright © 2011 Terms and Conditions

A theoretical graph shows the effects of increased production (red) or decreased clearance (blue) as possibilities for altered β-amyloid metabolism. Image courtesy of R. Bateman. Cell 2011 144, DOI: (10.1016/j.cell.2011.01.027) Copyright © 2011 Terms and Conditions