Extracellular mitochondria cause neutrophil recruitment.

Slides:

Advertisements

Similar presentations

Synergistic antitumor effect of anti-CD40/CpG and 14

Advertisements

Antitumor effect of the combination of IL-2 IC and anti–CTLA-4.

Interferon‐β Modulates Inflammatory Response in Cerebral Ischemia

Anti-CD40 and CpG induce activation of T cells in draining lymph nodes

Resveratrol modulates DSS-induced neutrophils during colitis.

Sex differences in resident immune cell phenotype underlie more efficient acute inflammatory responses in female mice by Ramona S. Scotland, Melanie J.

TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation by Benyue Zhang, Damilola Oyewole-Said,

Levels of cytokines and chemokines in TPL-treated (from ED2) and control (H2O) mice at midgestation (ED10). Levels of cytokines and chemokines in TPL-treated.

Systemic administration of attenuated Salmonella choleraesuis in combination with cisplatin for cancer therapy Che-Hsin Lee, Chao-Liang Wu, Yun-Sheng.

Effects of Intravenous Immunoglobulins on Mice with Experimental Epidermolysis Bullosa Acquisita Misa Hirose, Benjamin Tiburzy, Norito Ishii, Elena Pipi,

Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. Combined A2A receptor and PD-1 blockade is not effective in IFNγ−/− mice. AT-3ovadim.

Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG mice. Viral load and CD4+ T cells in CD8+ T cell–depleted YU-2–infected MISTRG.

Fig. 8. mRIPO elicits neutrophil influx followed by DC and T cell infiltration into tumors. mRIPO elicits neutrophil influx followed by DC and T cell infiltration.

Combination Therapy Using IL-2 and Anti-CD25 Results in Augmented Natural Killer Cell–Mediated Antitumor Responses William H.D. Hallett, Erik Ames, Maite.

DQ661 improves survival in colon cancer model and potentiates activity of gemcitabine in KPC pancreatic cancer syngeneic model. DQ661 improves survival.

Mean and difference Raman spectra of T cells isolated from spleen of sham mice and endotoxemic mice for time points 1, 4, 10, and 30 d. Mean and difference.

Serum levels of IL-21 are elevated in a subset of patients with IM

Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Sustained HIV infection with CXCR4-tropic NL4-3 in MISTRG and MITRG mice. Analogously.

Numerous protumorigenic proteins are largely unaltered by obesity.

Association of sputum colour score with (A) total cell counts; (B) neutrophil proportion; (C) neutrophil number and (D) CXCL-8 concentration. Association.

Mitochondrial cardiolipin plays a key role in macrophage inflammasome activation in response to apoptotic mitochondria. Mitochondrial cardiolipin plays.

GM-CSF–producing γδT cells are involved in the development of EAM

Human T cells undergoing apoptosis and necroptosis release mitochondria, and apoptotic mitochondria recruit neutrophils. Human T cells undergoing apoptosis.

Antitumor effects of FF and gemcitabine on two pancreatic PDX models.

Apoptosis and necroptosis result in mitochondria dysfunction and injury. Apoptosis and necroptosis result in mitochondria dysfunction and injury. L929.

Loss of DGKζ and Cbl-b results in a greater percentage of splenic CD8+ T cells with an activated phenotype. Loss of DGKζ and Cbl-b results in a greater.

Macrophages uptake extracellular mitochondria from apoptotic cells, inducing caspase-1 activation and IL-1β production. Macrophages uptake extracellular.

Apoptosis and necroptosis of L929 cells results in the release of mitochondria. Apoptosis and necroptosis of L929 cells results in the release of mitochondria.

Anti-CD96 combines with anti–CTLA-4 or anti–PD-1 to suppress experimental and spontaneous lung metastases. Anti-CD96 combines with anti–CTLA-4 or anti–PD-1.

PRG‐1R346T: loss‐of‐function mutation reduced LPA internalization due to altered O‐glycosylation PRG‐1R346T: loss‐of‐function mutation reduced LPA internalization.

CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair depigmentation CNP520 treatment of male C57/BL6 mice for 8 weeks did not cause hair.

“Responders” and “off-responders” proportions.

β-Glucans do not modulate epithelial IL-33 or AHR.

How Fungi Have Shaped Our Understanding of Mammalian Immunology

Macrophage-resident NRP1 mitigates cytokine release and proinflammatory polarization. Macrophage-resident NRP1 mitigates cytokine release and proinflammatory.

Human T cells undergoing apoptosis and necroptosis release mitochondria, and apoptotic mitochondria recruit neutrophils. Human T cells undergoing apoptosis.

Experimental design for serological analyses.

IFN-γ–producing cells in the spleen and lungs postimmunization.

Immune-mediated tumor control by necroptotic cells requires NF-κB activation within dying cells but not MLKL-mediated cell lysis and DAMP release. Immune-mediated.

Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. Tumor control by necroptotic cells requires BATF3+cDC1 and CD8+leukocytes. (A)

Mouse lymphoma model. Mouse lymphoma model. A, EL-Arf−/− cells (1 × 106) were tail-vein injected into C57BL/6 mice. LNIWC imaging was separated into 2.

NOX1-deficient mice do not respond to GKT771 and exhibit reduced B16-F10 tumor growth associated with decreased production of angiogenic factors and minor.

PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors. PD1 targeting alters the recruitment of immune cells to MC38 CRC tumors. MC38.

Slc7a5 expression in preosteoclasts is reduced in ovariectomized mice.

LG NK cells appear to be conventional in phenotype.

IL-27 induces expression of multiple IR by CD8+ T cells.

Post-operative a) neutrophil counts, but not b) lymphocyte or c) platelet counts, were higher in current smokers than ex-smokers. #: time-points were statistically.

Mice immunized twice with RRBC showed superior protection to tumor challenge with αGal-positive MC38 colon carcinoma cells compared with mock-immunized.

Treatment effects of fenretinide (4-HPR, 5 μmol/L), 2-ME (2

PRIMA-1Met inhibits the growth of multiple myeloma tumors with mutant p53 in vivo. PRIMA-1Met inhibits the growth of multiple myeloma tumors with mutant.

Anti-Flk-1 treatment inhibits growth of s. c. 4T1 and B16 tumors. s. c

Primary B16F10 tumor inhibits experimental metastasis formation in the lung. Primary B16F10 tumor inhibits experimental metastasis formation in the lung.

Volume 25, Issue 13, Pages e4 (December 2018)

Fig. 2. PlGF-2123–144 conjugation reduces systemic exposure to checkpoint blockade Abs and potential treatment-related toxicity. PlGF-2123–144 conjugation.

Fig. 4 IP6K1-mediated polyP production by platelets plays a critical role in LPS-induced NPA formation. IP6K1-mediated polyP production by platelets plays.

Apoptotic cell index percentage (a and b) and mitotic cell index percentage (c and d) in small intestinal (a and c) and midcolonic (b and d) crypts of.

A to C, MetMAb shows strong antitumor activity in the KP4 orthotopic model of pancreatic cancer by ultrasound. A to C, MetMAb shows strong antitumor activity.

Characterization of mutant flagellin proteins.

Subodh Verma et al. BTS 2018;3:

MGA271 exhibits potent in vivo antitumor activity toward tumor cell carcinoma xenografts. MGA271 exhibits potent in vivo antitumor activity toward tumor.

Cross-presentation of ova to ova-specific CD8+ T cells in vivo by ova-loaded gp96 surface-expressing tumor cells. Cross-presentation of ova to ova-specific.

miR-146a is highly expressed selectively on γδ27− T cells.

Mechanisms of FRC-dependent myeloid cell recruitment.

Mice with a B cell–specific deletion of Ets1 do not have increased CD4+ T cell activation. Mice with a B cell–specific deletion of Ets1 do not have increased.

TNF-dependent communication between FALC FRCs and myeloid cells.

MDSC population in patient peripheral blood.

E2 induces IL-17–producing γδ+ T cells in the FGT

Fig. 6 Pharmacologic alterations of β-AR signaling regulate cardiomyocyte abscission and endowment. Pharmacologic alterations of β-AR signaling regulate.

In response to allergen, T cells and ILCs are equally important sources of IL-13. In response to allergen, T cells and ILCs are equally important sources.

Active Alp1 protease induces both AHR and eosinophilic inflammation.

Presentation transcript:

Extracellular mitochondria cause neutrophil recruitment. Extracellular mitochondria cause neutrophil recruitment. (A) C57BL/6 mice received i.p. injections of mitochondria (300 mg) isolated from healthy, apoptotic, or necroptotic L929 cells (n = 6 per group), or with an equal volume of PBS (vehicle control; n = 6), or with zymosan (positive control; 100 mg; n = 2). PECs were harvested 18 h after injection, and neutrophils were enumerated based on FACS analysis for Ly6G+Ly6B.2+ cells. (B) PEC neutrophils were enumerated and compared. Comparisons were performed using a Kruskal–Wallis with Dunn multiple comparison test. A p value <0.05 was considered significant. Minghua Zhu et al. ImmunoHorizons 2018;2:384-397 Copyright © 2018 The Authors