Tropheryma whipplei associated with diarrhoea in young children F. Fenollar, P. Minodier, A. Boutin, R. Laporte, V. Brémond, G. Noël, S. Miramont, H. Richet, S. Benkouiten, J.-C. Lagier, J. Gaudart, J.- L. Jouve, D. Raoult  Clinical Microbiology and Infection  Volume 22, Issue 10, Pages 869-874 (October 2016) DOI: 10.1016/j.cmi.2016.07.005 Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Microbiological data from stools of 155 children with diarrhoea. Clinical Microbiology and Infection 2016 22, 869-874DOI: (10.1016/j.cmi.2016.07.005) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Wavelet analysis of the relationship between children with diarrhoea with Tropheryma whipplei and children without diarrhoea with T. whipplei. (a) Analysis for the time series of T. whipplei in children without diarrhoea (TW+GE−) prevalence. (b) Analysis for the time series of T. whipplei in children with diarrhoea (TW+GE+) prevalence. (c) Phases for the two series. For (a) and (b), detection of periodic signals is performed within a confidence cone that excludes edge effects. Statistical significance of the period was assessed by the bootstrap method and statistically significant zones are circled with dashed lines. Period maxima are shown by white lines. For (a) and (b), the x-axes represent the time line (weeks) and the y-axes the period (quarters). Colours represent the spectra: dark red for high spectra (where periods are detected) and dark blue for low spectra (for less possible period). (c) Phase analysis, shows the phases for TW+GE− time series (dark line) and TW+GE+ time series (dashed line). The phase lag (and its evolution through time) is represented by the dashed-point line. The x-axis represents the time line (weeks) and the y-axis the phase (between pi and −pi). Clinical Microbiology and Infection 2016 22, 869-874DOI: (10.1016/j.cmi.2016.07.005) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Tropheryma whipplei evolution within and between years. (a) Number of specimens positive for T. whipplei among children with diarrhoea and those without, per month. (b) Number of specimens positive for T. whipplei per month. Clinical Microbiology and Infection 2016 22, 869-874DOI: (10.1016/j.cmi.2016.07.005) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions