Satoshi Itami, Shigeki Inui

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Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle Satoshi Itami, Shigeki Inui Journal of Investigative Dermatology Symposium Proceedings Volume 10, Issue 3, Pages 209-211 (December 2005) DOI: 10.1111/j.1087-0024.2005.10107.x Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Expression of androgen receptor, type I, and type II 5α reductase in human cultured dermal papilla cells from various body sites. AR, androgen receptor; 5αR-I, type I 5α-reductase; 5αR-II, type II 5α reductase. Journal of Investigative Dermatology Symposium Proceedings 2005 10, 209-211DOI: (10.1111/j.1087-0024.2005.10107.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Effect of androgen on the proliferation of keratinocytes (KC) co-cultured with dermal papilla cells (DPC) from various body sites transiently transfected with pSG5-AR. KC were co-cultured with beard (lanes 1 and 2), bald frontal (lanes 3 and 4), non-bald frontal (lanes 5 and 6), or occipital DPC (lanes 7 and 8) transfected with pSG5-AR. The cells were cultured in the absence (lanes 1, 3, 5, and 7) or in the presence of 10-9 M R1881 (lanes 2, 4, 6, and 8) for 4 d. Each bar represents the mean±SD of three independent experiments using a different set of cell lines. *p<0.05, **p<0.01 versus the respective controls. (modified from figures inInui et al, 2002) Journal of Investigative Dermatology Symposium Proceedings 2005 10, 209-211DOI: (10.1111/j.1087-0024.2005.10107.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Schematic diagram of androgen action in human hair follicles. For the beard growth stimulation by androgen, insulin-like growth factor-I (IGF-I) acts as the paracrine mediator from dermal papilla cells (DPC) to epithelial cells. On the other hand, transforming growth factor-β1 (TGF-β1) is an androgen-dependent paracrine mediator for androgenetic alopecia. Journal of Investigative Dermatology Symposium Proceedings 2005 10, 209-211DOI: (10.1111/j.1087-0024.2005.10107.x) Copyright © 2005 The Society for Investigative Dermatology, Inc Terms and Conditions