Volume 83, Issue 4, Pages (April 2013)

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Volume 83, Issue 4, Pages 553-556 (April 2013) Proton pump inhibitors and hypomagnesemia: a rare but serious complication Mark A. Perazella Kidney International Volume 83, Issue 4, Pages 553-556 (April 2013) DOI: 10.1038/ki.2012.462 Copyright © 2013 International Society of Nephrology Terms and Conditions

Figure 1 Intestinal and renal magnesium (Mg2+) transport. (a) Mg2+ absorption in the gastrointestinal tract. Mg2+ is absorbed either passively through paracellular pathways (red dashed lines) or actively through transient receptor potential melastatin-6 and -7 (TRPM6/7) channels (solid black lines) within enterocytes. Mg2+ ultimately enters the portal vein. (b) Mg2+ reabsorption in the renal distal convoluted tubule. Mg2+ enters the cell via TRPM6, which is shuttled to the apical membrane following binding of epidermal growth factor (EGF) to its receptor (EGFR). Mg2+ then exits the cell via the basolateral membrane into the peritubular capillaries. The sodium chloride cotransporter (NCC) on the apical membrane actively transports NaCl into the cell. Kidney International 2013 83, 553-556DOI: (10.1038/ki.2012.462) Copyright © 2013 International Society of Nephrology Terms and Conditions