How the Gut Feels, Smells, and Talks

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How the Gut Feels, Smells, and Talks Joep Beumer, Hans Clevers Cell Volume 170, Issue 1, Pages 10-11 (June 2017) DOI: 10.1016/j.cell.2017.06.023 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Identification of the Sensory Repertoire of EC Cells and Contact to Nerve Fibers (A) Bellono et al. utilize the murine intestinal organoid system to identify molecules that activate serotonin-producing EC cells. Calcium recording after addition of a library of molecules to organoids showed a variety of stimuli that can induce EC activation, normally found in food (AITC), released by microbiota (Isovalerate) or that are endogenously produced (Catecholamines). RNA sequencing revealed a set of receptors that could render EC cells sensitive to these stimuli, and genetic and pharmalogical inhibition confirmed their role as EC sensors. (B) Serotonin release from EC cells (red) is induced through a calcium influx after ligand-receptor interaction, in this example the binding of Isovalerate produced by microbiota to Olfr558. Serotonin from EC cells causes activation of afferent nerve fibers through synaptic interactions. Cell 2017 170, 10-11DOI: (10.1016/j.cell.2017.06.023) Copyright © 2017 Elsevier Inc. Terms and Conditions