Fiber innervation is reduced in both central and peripheral targets of DRG neurons in Nav-Tsc2 mice. Fiber innervation is reduced in both central and peripheral.

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Fiber innervation is reduced in both central and peripheral targets of DRG neurons in Nav-Tsc2 mice. Fiber innervation is reduced in both central and peripheral targets of DRG neurons in Nav-Tsc2 mice. A, B, Projection of a z-stack of hindpaw glabrous skin labeled with TuJ1. Arrowhead shows aberrant fiber morphology in Nav-Tsc2 mice. Dotted line denotes epidermal-dermal border. Scale bar: 50 µm. C, Number of TuJ1-positive fibers crossing the epidermal-dermal border were counted in control and Nav-Tsc2 mice; N = 5. D, E, Confocal micrographs of Rosa-GFP reporter in control and Nav-Tsc2 lumbar spinal cord transverse sections labeled with IB4. Laminas I and II used for quantification are outlined. Scale bar: 50 µm. F, Normalized area fraction of GFP signal in Laminas I and II; N = 5. Individual animals plotted with mean ± SEM; *p < 0.05, ***p < 0.001, ****p < 0.0001. Dan Carlin et al. eNeuro 2018;5:ENEURO.0436-17.2018 ©2018 by Society for Neuroscience