Luis A. Solchaga, Ph. D. , Johnna S. Temenoff, Ph. D. , Jizong Gao, M

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Presentation transcript:

Repair of osteochondral defects with hyaluronan- and polyester-based scaffolds Luis A. Solchaga, Ph.D., Johnna S. Temenoff, Ph.D., Jizong Gao, M.D., Ph.D., Antonios G. Mikos, Ph.D., Arnold I. Caplan, Ph.D., Victor M. Goldberg, M.D. Osteoarthritis and Cartilage Volume 13, Issue 4, Pages 297-309 (April 2005) DOI: 10.1016/j.joca.2004.12.016 Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 1 SEM of the scaffolds. Osteoarthritis and Cartilage 2005 13, 297-309DOI: (10.1016/j.joca.2004.12.016) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 2 Light microscopy of the osteochondral defects 4 weeks after implantation. Panels in the left column depict toluidine blue-stained specimens of each treatment group (20×); panels in the right column display the areas within the boxes stained with antibodies against type II collagen (75×). Osteoarthritis and Cartilage 2005 13, 297-309DOI: (10.1016/j.joca.2004.12.016) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 3 Light microscopy of the osteochondral defects 12 weeks after implantation. Panels in the left column depict toluidine blue-stained specimens of each treatment group (20×); panels in the right column display the areas within the boxes stained with antibodies against type II collagen (75×). Osteoarthritis and Cartilage 2005 13, 297-309DOI: (10.1016/j.joca.2004.12.016) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 4 Light microscopy of the osteochondral defects 20 weeks after implantation. Panels in the left column depict toluidine blue-stained specimens of each treatment group (20×); panels in the right column display the areas within the boxes stained with antibodies against type II collagen (75×). Osteoarthritis and Cartilage 2005 13, 297-309DOI: (10.1016/j.joca.2004.12.016) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions

Fig. 5 Histomorphometric analysis. Pie charts representing the relative amounts of different tissues found within the cartilaginous (A) and bony (B) compartments of the defect for each scaffold and time point. The means for each treatment group and time point are displayed here. Osteoarthritis and Cartilage 2005 13, 297-309DOI: (10.1016/j.joca.2004.12.016) Copyright © 2005 OsteoArthritis Research Society International Terms and Conditions