Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity Akira Iyoda, MD, Kenzo Hiroshima, MD, Yasumitsu Moriya, MD, Teruaki.

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Pulmonary large cell neuroendocrine carcinoma demonstrates high proliferative activity Akira Iyoda, MD, Kenzo Hiroshima, MD, Yasumitsu Moriya, MD, Teruaki Mizobuchi, MD, Mizuto Otsuji, MD, Yasuo Sekine, MD, Kiyoshi Shibuya, MD, Toshihiko Iizasa, MD, Yukio Saitoh, MD, Takehiko Fujisawa, MD The Annals of Thoracic Surgery Volume 77, Issue 6, Pages 1891-1895 (June 2004) DOI: 10.1016/j.athoracsur.2003.10.119

Fig 1 Immunohistochemical staining for anti Ki-67 antibody in large cell neuroendocrine carcinoma. (×40). The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)

Fig 2 Immunohistochemical staining for anti Ki-67 antibody in classic large cell carcinoma. (×40). The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)

Fig 3 Immunohistochemical staining for anti P53 protein antibody in large cell neuroendocrine carcinoma. (×40). The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)

Fig 4 Immunohistochemical staining for anti P53 protein antibody in classic large cell carcinoma. (×40). The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)

Fig 5 Immunohistochemical staining for anti Bcl-2 antibody in large cell neuroendocrine carcinoma. (×40). The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)

Fig 6 Immunohistochemical staining for anti Bcl-2 antibody in classic large cell carcinoma. (×40). The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)

Fig 7 The disease specific disease-free survival analysis indicates that LCNEC cases with stage 1 disease had a significantly poorer prognosis than CLCC cases with stage 1 disease. (LCNEC = large cell neuroendocrine carcinoma; CLCC = classic large cell carcinoma.) The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)

Fig 8 The disease specific disease-free survival analysis indicates that LCNEC cases without adjuvant chemotherapy had a significantly poorer prognosis than CLCC cases without adjuvant chemotherapy. (LCNEC = large cell neuroendocrine carcinoma; CLCC = classic large cell carcinoma.) The Annals of Thoracic Surgery 2004 77, 1891-1895DOI: (10.1016/j.athoracsur.2003.10.119)